돌발성 난청 환자에서 고용량 스테로이드 요법과 초고용량 스테로이드 요법의 치료 효과 비교

박현호; 최재혁; 허은정; 이태훈; 남정권; 권중근

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자료유형: 학술저널

저자정보: 박현호 최재혁 허은정 이태훈 남정권 권중근

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제7호

발행연도: 2009.1

수록면: 566 - 571 (6page)

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연구주제

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연구배경

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연구방법

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연구결과

초록· 키워드

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Background and Objectives Corticosteroids have been used for therapeutic management of sudden sensorineural hearing loss (SSNHL). Because the levels of steroid within inner ear after systemic administration is very low, high-dose steroid regimens have been used. The purpose of this study is to compare the effect of high-dose (HD) steroid therapy with that of super-highdose (SHD) steroid therapy in SSNHL. Subjects and Method The study group consisted of 97 patients diagnosed as SSNHL. They were divided into two groups: those who were administered 60 mg prednisolone as the initial high dose (HD group) and those who were administered 1,200 mg hydrocortisone (≒300 mg prednisone) as the super high dose (SHD group). Results Hearing improvement was observed in 76.8% of HD group and in 67.9% of SHD group and there was no statistically significant difference in the rate of hearing improvement between HD group and SHD group. Conclusion Super-high-dose steroid regimen is not superior to high-dose steroid regimen in the treatment of SSNHL.

#Sudden hearing loss·Steroids

참고문헌 (20)

참고문헌 신청

Aoki D / 2006 / Evaluation of super-high-dose steroid therapy for sudden sensorineural hearing loss / Otolaryngol Head Neck Surg 134 (5) : 783 ~ 787

Byl FM Jr / 1984 / Sudden hearing loss: eight years; experience and suggested prognostic table / Laryngoscope 94 (5) : 647 ~ 661

Cohn LA / 1997 / Glucocorticosteroids as immunosuppressive agents / Semin Vet Med Surg (Small Anim) 12 (3) : 150 ~ 156

Drayer JI / 1984 / The effects of steroid hormones on vascular tissue / J Cardiovasc Pharmacol 6 (2) : 394 ~ 400

Fetterman BL / 1996 / Prognosis and treatment of sudden sensorineural hearing loss / Am J Otol 17 (4) : 529 ~ 536

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