Intratympanic Steroids in Severe to Profound Sudden Sensorineural Hearing Loss as Salvage Treatment

이종대; 박무균; 이치규; 박계훈; 이병돈

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자료유형: 학술저널

저자정보: 이종대 박무균 이치규 박계훈 이병돈

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제3호

발행연도: 2010.1

수록면: 122 - 125 (4page)

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연구주제

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연구배경

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연구방법

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연구결과

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Objectives. Intratympanic steroids are being increasingly used in the treatment of sudden sensorineural hearing loss (SSNHL)after the failure of systemic therapy. This study evaluated the efficacy of administering intratympanic dexamethasone (ITD) as a salvage treatment for severe to profound SSNHL. Methods. We reviewed the medical records of patients who presented with severe to profound SSNHL between January 2007 and December 2009. ITD was given about 14 days after the initial systemic treatment. Successful recovery was defined as complete or partial recovery using Sigel’s criteria. We compared the results of treatment between the severe SSNHL (S-SSNHL) and profound SSNHL (P-SSNHL) groups. Results. All the patients in the S-SSNHL group showed significant improvement, as compared to the P-SSNHL group (P=0.017). The recovery rate after the initial systemic treatment was 36% (9/25) in the S-SSNHL group and 18.1% (4/22) in the P-SSNHL group (P=0.207). In comparison, the recovery rate of ITD as a salvage treatment was 37.5% (6/16) in the S-SSNHL group and 5.5% (1/18) in the P-SSNHL group (P=0.03). Conclusion. Our comparative study dose not support the efficacy of ITD as salvage treatment for patients with P-SSNHL as compared with that for S-SSNHL. We recommend that patients with P-SSNHL be informed about the low efficacy of ITD as a salvage treatment.

#Sudden sensorineural hearing loss #Intratympanic #Steroid

참고문헌 (15)

참고문헌 신청

Ahn JH / 2008 / Can intratympanic dexamethasone added to systemic steroids improve hearing outcome in patients with sudden deafness? / Laryngoscope 118 (2) : 279 ~ 282

Battaglia A / 2008 / Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss / Otol N

Byl FM Jr / 1984 / Sudden hearing loss: eight years’ experience and suggested prognostic table / Laryngoscope 94 (5 Pt 1) : 647 ~ 661

Chandrasekhar SS / 2000 / Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Nec / Otolar

Han CS / 2009 / Clinical efficacy of initial intratympanic steroid treatment on sudden sensorineural hearing loss with diabetes / Otolaryngol Head Neck Surg 141 (5) : 572 ~

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