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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 565 - 569 (5page)
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초록· 키워드
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Background and Objectives The biological activity in antibacterial and antioxidative action of essential oils (EOs) have been investigated. In this study, we tried to evaluate the effects of Chamaecyparis obtusa EOs on producing chemical mediators by peripheral blood mononuclear cells (PBMCs).
Subjects and Method PBMCs from healthy volunteers were stimulated with lipopolysaccharide (LPS) and phytohaemagglutinin (PHA) in the presence of varying concentrations of EOs. Cytotoxic effects of EOs were measured using an aqueous cell proliferation assay kit and supernatants were analyzed using enzyme-linked immunosorbent assay. Tumor necrosis factor-α (TNF-α), interleukin-5, and interferon-γ (INF-γ) protein levels were measured to determine the anti-inflammatory effects of essential oil.
Results EOs were found to have cytotoxic effects on PBMCs at levels of over 1%. EOs not only could induce PBMCs to produce chemical mediators, but it also significantly inhibited the LPS induced TNF-α and INF-γ productions as well as the PHA induced INF-γ production.
Conclusion EOs had cytotoxic effects at high concentrations and modulated chemical mediator productions from PBMC. These data suggest that EOs could be used to treat immunologic or inflammatory diseases. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(11):565-9
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Abe T / 2008 / Antioxidant effects and antimicrobial activites of phytoncide / Biocontrol Sci 13 (1) : 23 ~ 27
Ahn JY / 2004 / Biological activities of essential oil from Chamaecyparis obtusa / J Soc Coset Scientist Korea 30 (4) : 503 ~ 507
An BS / 2013 / Antiinflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats / Mol Med Rep 8 (1) : 255 ~ 259
Caldefie-Chezet F / 2006 / Potential anti-inf lammatory effects of Melaleuca alternifolia essential oil on human peripheral blood leukocytes / Phytother Res 20 (5) : 364 ~ 3
Chou ST / 2013 / Achillea millefolium L. essential oil inhibits LPS-induced oxidative stress and nitric oxide production in RAW 264.7 Macrophages / Int J Mol Sci 14 (7) : 12
Ahn JY / 2004 / Biological activities of essential oil from Chamaecyparis obtusa / J Soc Coset Scientist Korea 30 (4) : 503 ~ 507
An BS / 2013 / Antiinflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats / Mol Med Rep 8 (1) : 255 ~ 259
Caldefie-Chezet F / 2006 / Potential anti-inf lammatory effects of Melaleuca alternifolia essential oil on human peripheral blood leukocytes / Phytother Res 20 (5) : 364 ~ 3
Chou ST / 2013 / Achillea millefolium L. essential oil inhibits LPS-induced oxidative stress and nitric oxide production in RAW 264.7 Macrophages / Int J Mol Sci 14 (7) : 12
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