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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 291 - 303 (13page)
이용수
초록· 키워드
오류제보하기
GV1001 is a peptide derived from the human telomerase reverse transcriptase (hTERT) sequence that is reported to have anti-cancer and anti-inflammatory effects. Enolase1 (ENO1) is a glycolytic enzyme, and stimulation of this enzyme induces high levels of pro-inflammatory cytokines from concanavalin A (Con A)-activated peripheral blood mononuclear cells (PBMCs) and ENO1-expressing monocytes in healthy subjects, as well as from macrophages in rheumatoid arthritis (RA) patients. Therefore, this study investigated whether GV1001 downregulates ENO1-induced pro-inflammatory cytokines as an anti-inflammatory peptide. The results showed that GV1001 does not affect the expression of ENO1 in either Con A-activated PBMCs or RA PBMCs. However, ENO1 stimulation increased the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, and these cytokines were downregulated by pretreatment with GV1001. Moreover, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB were activated when ENO1, on the surface of Con A-activated PBMCs and RA PBMCs, was stimulated, and they were successfully suppressed by pre-treatment with GV1001. These results suggest that GV1001 may be an effective anti-inflammatory peptide that downregulates the production of pro-inflammatory cytokines through the suppression of p38 MAPK and NF-κB activation following ENO1 stimulation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
[학술지(정기간행물)] - Middleton, G. / 2014 / Gemcitabine capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac):an open-label, randomised, phase 3 trial / Lancet Oncol 15 : 829 ~ 840
[학술지(정기간행물)] - Staff, C. / 2014 / Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients / Int. J. Oncol 45 : 1293 ~ 1303
[학술지(정기간행물)] - Annels, N. E. / 2014 / The effects of gemcitabine capecitabine combination chemotherapy of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer / Cancer Immunol. Immunother 63 : 175 ~ 183
[학술지(정기간행물)] - Brunsvig, P. F. / 2011 / Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy an 8-year update on a phase I/II trial / Clin. Cancer Res 17 : 6847 ~ 6857
[학술지(정기간행물)] - Hunger, R. E. / 2011 / Vaccination of patients with cutaneous melanoma with telomerase-specific peptides / Cancer Immunol. Immunother 60 : 1553 ~ 1564
[학술지(정기간행물)] - Staff, C. / 2014 / Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients / Int. J. Oncol 45 : 1293 ~ 1303
[학술지(정기간행물)] - Annels, N. E. / 2014 / The effects of gemcitabine capecitabine combination chemotherapy of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer / Cancer Immunol. Immunother 63 : 175 ~ 183
[학술지(정기간행물)] - Brunsvig, P. F. / 2011 / Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy an 8-year update on a phase I/II trial / Clin. Cancer Res 17 : 6847 ~ 6857
[학술지(정기간행물)] - Hunger, R. E. / 2011 / Vaccination of patients with cutaneous melanoma with telomerase-specific peptides / Cancer Immunol. Immunother 60 : 1553 ~ 1564
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UCI(KEPA) : I410-ECN-0101-2016-511-002258972