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Background and Objectives The aim of this study was to evaluate surgical completeness inendoscopic total thyroidectomy with central neck dissection via unilateral axillo-breast approach(UABA) compared with bilateral axillo-breast (BABA) and open approach (OA) by means ofthe radioactive iodine uptake (RAIU) ratio and thyroglobulin (Tg) of remnant thyroid. Subjects and Method From July 2010 to March 2013, 82 patients who had underwent totalthyroidectomy with central neck dissection and postoperative radioactive iodine (RAI) ablationfor papillary thyroid carcinoma were enrolled. Of these patients, 27 patients underwent UABA,24 patients BABA, and 31 patients OA. Clinicopathologic data, surgical outcome, stimulated Tgand RAIU ratio on the first postoperative RAI ablation scan were compared among 3 groups. Results Patients in the endoscopic surgery groups (UABA, BABA) were younger than thosein the OA groups. Invasiveness such as operation time, postoperative pain, and drain amount inUABA was less than that in BABA and severer than that in OA. Other variables regarding clinicopathologicand surgical data were not significantly different. Stimulated Tg and RAIU ratiodid not show significant differences among 3 groups (p=0.659 and p=0.664). Conclusion The completeness of UABA was comparable with that of BABA and OA. TheUABA may be a safe option for patients who need endoscopic thyroidectomy for papillarythyroid carcinoma.

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