하인두 편평세포암에서 간세포성장인자와 그 수용체인 c-Met의 발현

문성균; 배준호; 김철호; 한재호; 최은창; 이재호

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자료유형: 학술저널

저자정보: 문성균 배준호 김철호 한재호 최은창 이재호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제11호

발행연도: 2004.1

수록면: 1,135 - 1,141 (7page)

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Hepatocyte growth factor (HGF), a potent stimulator of hepatocyte growth, stimulates motility, invasivenes, proliferation, and morphogenesis of epithelium, and may be involved in physiologic and pathologic proceses such as embryogenesis, wound healing, organ regeneration, inflamation, and tumor invasion. So we examined the role of the HGF/c-Met on invasion and metastasis of hypopharyngeal squamous cell carcinoma ( ). We performed imunohistochemical stains on 40 normal mu-cosas and 40 SCs of hypopharynx with HGF antibody and c-Met antibody. For RT-PCR and Western blot, fresh normal tisues and cancer tisues in hypopharynx obtained from five patients were used. The positive rates of HGF and c-Met expression in hypopharyngeal SC were 77.5% and 70%, respectively. HGF staining was significantly correlated with lymph node metastasis and pathologic stage (p<0.05). c-Met staining was only significantly corelated with lymph node metastasis (p<0.05). The inc-reased expresssion of c-Met mRNA (RT-PCR) and protein (Western Blot) were detected in hypopharyngeal cancer tisue. These results suggest that HGF may play an important role in the progression of hypopharyngeal cancer.

#간세포성장인자 #HGF)·c-Met·하인두암. #Hepatocyte Growth Factor #HGF)· c-Met· Hypopharyngeal cancer.

참고문헌 (20)

참고문헌 신청

/ 1984 / Control ofhepatocyte replication by two serum factors 44 : 4414 ~ 4419

/ 1984 / Partial characterization ofa hepatocyte growth factor from rat platelets 119 : 183 ~ 192

/ 1984 / Partial purification and characterizationof hepatocyte growth factor from serum of hepatectomizedrats 122 : 1450 ~ 1459

/ 1989 / Molecular cloning and expression of human hepatocytegrowth factor 342 : 440 ~ 443

/ 1990 / Scatterfactor. Molecular characteristics and effect on the invasiveness ofepithelial cells. 111 : 2097 ~ 2108

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