NAT2, TNF-α, TGF-β 유전자 유형이 한국인의알레르기 비염 발생에 미치는 영향

박윤근; 강종원; 김용대; 이철호; 엄상용; 김헌

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자료유형: 학술저널

저자정보: 박윤근 강종원 김용대 이철호 엄상용 김헌

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제12호

발행연도: 2006.1

수록면: 1,165 - 1,171 (7page)

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Background and Objectives：The inflammatory reaction is affected by the genotype or phenotype of genes related with inflammationmodulating cytokines and allergen metabolizing enzyme. This study was performed to investigate the relationshipbetween N-acetyl transferase 2 (NAT2), tumor necrosis factor-α(TNF-α), transforming growth factor-β(TGF-β) and theallergic rhinitis in Korea. Subjects and Method：One hundred forty five allergic rhinitis patients and 167 controls were included.Venous blood samples were collected and the genotypes were analyzed by PCR technique. NAT2 phenotypes were designatedas ‘high’, ‘medium’ and ‘low’ by known genotype-phenotype relationship. TNF-αgenotypes were classified as ‘A/A’,‘A/G’ and ‘G/G’. TGF-βgenotype was classified as ‘Arg/Arg’, ‘Arg/Pro’ and ‘Pro/Pro’. These data were analyzed by SAS forwindows ver 8.02. Results：The phenotype of NAT2 and genotype of TGF-βshowed no significant effect on allergic rhinitis.G/G or G/A genotype of TNF-αsignificantly increases the risk of allergic rhinitis. High activity phenotype of NAT2 showedhigher level of total serum IgE. Conclusion：Genetic factors including TGF-βare important in the development of allergicrhinitis in Korea. NAT2 phenotype affect allergic reaction. (Korean J Otolaryngol 2006;49:1165-71)

#알레르기 비염·NAT2·TNF-α·TGF-β. #Allergic rhinitis·NAT2·TNF-α·TGF-β.

참고문헌 (18)

참고문헌 신청

/ 1994 / Comparison between skin testing andin vitro testing for diagnosis of allergen in athmatic children : 246 ~ 50

/ 1995 / TNF alpha is localized to nasal mucosal mast cells andis released in acute allergic rhinitis 25 (5) : 406 ~ 415

/ 1996 / Environmental factors and respiratory hypersensitivity:The Americas 86 : 115 ~ 130

/ 2000 / A cluster of seven tightly linked polymorphisms in the IL-13gene is associated with total serum IgE levels in three populations ofwhite childen 105 (3) : 506 ~ 513

/ 2000 / Polymorphisms of the IL=4 and FcepsilonR gene and the risk of allergic disorder in at-risk infants 161 (5) : 1655 ~ 1659

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