Interleukin-10 발현 B 세포가 만성 비부비동염의 병태생리에 미치는 영향

박희성; 박수경; 연선희; Jun Xu; 나기상; 김용민

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자료유형: 학술저널

저자정보: 박희성 박수경 연선희 Jun Xu 나기상 김용민

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제61권 제8호

발행연도: 2018.1

수록면: 412 - 420 (9page)

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2018

IL-10 발현 B 세포가 만성 비부비동염의 병태생리에 미치는 영향

박희성 의학과 2018.01 학위논문

Interleukin-10 발현 B 세포가 만성 비부비동염의 병태생리에 미치는 영향

박희성 , 박수경 , 연선희 외 3명 대한이비인후-두경부외과학회지 2018.01 학술저널

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Background and Objectives Many kinds of inflammatory cells and cytokines are suggestedto be related with pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP),but its mechanism is not yet fully understood. In particular, little is known about the functionand role of Interleukin-10 (IL-10) producing regulatory B cells. The aim of this study was toinvestigate the presence and function of B cells, especially IL-10-producing regulatory Bcells, in the nasal polyp (NP) and nasal mucosa. Subjects and Method Twenty patients with CRSwNP, 10 patients with chronic rhinosinusitiswithout nasal polyp (CRSsNP) and 10 control subjects were enrolled in this study. NP tissuesand uncinate tissues were collected for analysis. Real-time polymerase chain reaction (RTPCR),immunohistochemistry were performed to measure the expression levels of the selectedinflammatory cytokines and inflammation-associated molecules. Results In the mucosal tissues of CRSsNP patients, the number of IL-10+ B cells was significantlylower than that of NP and control mucosa of CRSwNP patients. The number of IL-10+B cells was significantly increased in the eosinophilic NP, non-eosinohilic NP, CRSsNP, andcontrol groups. There was a significant positive correlation between the number of IL-10+ Bcells and B cell activating factor (BAFF). Conclusion The expression of IL-10+ B cells and BAFF was significantly increased inCRSwNP patients compared to CRSsNP patients and control mucosal tissues, and IL-10+ Bcells were more significantly increased in eosinophilic tissues. These results indicate that regulatoryB cells are involved in the pathophysiology of eosinophilic NP and that BAFF contributesto the production of regulatory B cells.

참고문헌 (24)

참고문헌 신청

Taylor MJ / 2002 / Detection of fungal organisms in eosinophilic mucin using a fluorescin-labelled chitin specific binding protein / Otolaryngol Head Neck Surg 127(5):377~383

Bachert C / 2002 / Staphylococcus aureus superantigens and airway disease / Curr Allergy Asthma Rep 2(3):252~258

Zhang N / 2008 / Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease / J Allergy Clin Immunol 122(5):961~968

Fokkens W / 2007 / European position paper on rhinosinusitis and nasal polyps 2007 / Rhinol Suppl 20:1~136

Sharma S / 2012 / Peripheral blood and tissue T regulatory cells in chronic rhinosinusitis / Am J Rhinol Allergy 26(5):371~379

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