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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국운동생리학회 운동과학 운동과학 제25권 제1호
발행연도
2016.1
수록면
10 - 17 (8page)

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PURPOSE: The purpose of this study was to analyze the changes of gene transcripts related to the resistance exercise performance after 4- and 8-weeks of resistance exercise training in rat skeletal muscle with using large-scale BeadArray containing probe sets for 22,523 genes. METHODS: Forty-eight male Sprague-Dawley rats were separated into control (CON, n=16) and exercise-trained groups (resistance training group, RT, n=32). After 4- and 8-weeks of resistance exercise, based upon lifting weight of individual rats, RT subsequently was separated into high performance group (H-RT4, n=8; H-RT8, n=8) and low performance group (L-RT4, n=8; L-RT8, n=8). Exercised rats were trained to climb a 1-m vertical (85 degree incline) ladder with weights secured to their tail, and performed 1 set of 10 times of 3 days per week for 8 weeks progressively. Skeletal muscle was taken from the flexor halucis longus (FHL) after 4- and 8-weeks exercise. After separating the total RNA of each group, large-scale gene expression was analyzed by BeadArray using Illunina RatRef-12 Expression BeadChip, and qPCR was used to inspect BeadArray data. We selected genes given the criteria that detection p-value to <0.01, M-value {M=log2(condition)-log2(reference)} to >1.0, and DiffScore to >30. RESULTS: The expression of 20 genes significantly increased 4 weeks after resistance exercise compared to L-RT4, and the expression of four genes decreased, including genes with unknown functions. At 8 weeks, the expression of one gene significantly increased compared to L-RT8 and that of one decreased. These genes involved in acute phase response (Hp, Ahsg), anti-inflammatory response (Ambp), C21-steroid hormone biosynthesis (Timp1), heme oxidation (Hmox1), muscle development (Myh6), regulation of cell growth (Igfbp1), vitamin D metabolism (Gc), calcium-mediated signaling (Dscr1), gluconeogenesis (Atf3), regulation of transcription (Nr4a3), and learning and memory (Egr1). CONCLUSIONS: This is the first study to use BeadArray to examine the global mRNA expression in rat skeletal muscle after resistance ladder training. We found expression genes of rat skeletal muscle according to the resistance exercise performance level using BeadArray. These results may help to explain previously reported physiological changes of the skeletal muscle and suggest new avenues for further investigation.
#BeadArray #resistance exercise #large-scale gene expression #candidate gene association study

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참고문헌 (33)

참고문헌 신청
Bray MS / 2009 / The human gene map for performance and health-related fitness phenotypes:the 2006-2007 update / Medicine and Science in Sports and Exercise 41(1):35~73 google schola Ahmetov II / 2015 / Current progress in Sports genomics / Advances in Clinical Chemistry 70:247~314 google schola Wong WC / 2008 / On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GenChip data its significance for biological interpretation / Biology Direct 3(1):23 google schola Boenning DA / 2001 / The future of clinical research: the role of genomics, informatics, and evidence-based medicine / Journal of Investigative Medicine 49(1):10~11 google schola Klein RJ / 2005 / Complement factor H polymorphism in age-relaed macular degeneration / Science 308(5720):385~389 google schola

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