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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 17 - 21 (5page)
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Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
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참고문헌 (33)
참고문헌 신청
Soumelis V / 2002 / Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP / Nat Immunol 3:673~680
Gao PS / 2010 / Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum / J Allergy Clin Immunol 125:1403~1407
Noble CL / 2008 / Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis / Gut 57:1398~1405
Noble CL / 2010 / Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis / Inflamm Bowel Dis 16:1717~1728
Olkhanud PB / 2011 / Thymic stromal lymphopoietinis a key mediator ob breast cancer progression / J Immunol 186:5656~5662
Gao PS / 2010 / Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum / J Allergy Clin Immunol 125:1403~1407
Noble CL / 2008 / Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis / Gut 57:1398~1405
Noble CL / 2010 / Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis / Inflamm Bowel Dis 16:1717~1728
Olkhanud PB / 2011 / Thymic stromal lymphopoietinis a key mediator ob breast cancer progression / J Immunol 186:5656~5662
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