지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 148 - 153 (6page)
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초록· 키워드
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Purpose: We investigated trends in antibiotic resistance for gram-negative bacteria in infants with a urinary tract infection (UTI) over 15 years at a single institution.
Methods: A retrospective chart review was conducted for children younger than 24 months who visited the emergency room and were diagnosed with a UTI between January 2000 and December 2014. We selected urine culture data that grew Escherichia coli and Klebsiella pneumoniae. Baseline clinical information and results of antimicrobial susceptibility tests were analyzed by dividing the 15-year study time frame into three periods (A: 2000-2004, B: 2005-2009, and C: 2010- 2014).
Results: During the study period, 478 applicable children were identified (E.
coli, 89.7% and K. pneumoniae, 10.3%). Antibiotic resistance to third-generation cephalosporins was increased from period A to period C (A, 2.1%; B, 8.3%; C, 8.8%; P=0.025). Resistance to quinolones also showed a steady pattern during periods A to C, although it was not statistically significant (A, 7.9%; B, 9.7%; C, 12.4%; P=0.221). The incidence of Extended-spectrum β-lactamase (ESBL)-producing gram-negative bacteria increased from period A to period C (A, 1.4%; B, 7.6%; C, 8.2%; P=0.012).
Conclusion: This study revealed that the common uropathogens E. coli and K.
pneumoniae experienced increasing resistance rates against third-generation cephalosporins and a constant antibiotic resistance to quinolones in children younger than 24 months. We also showed a recent increased incidence of ESBLproducing gram-negative bacteria in patients with community-acquired UTIs.
Therefore, it is necessary to actively surveil resistance in order to properly select empirical antibiotics.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Ahmed AM / 2007 / Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes / Applied and environmental microbiology 73 (20)
Aihua Wang / 2008 / Presence of qnr gene in Escherichia coli and Klebsiella pneumoniae resistant to ciprofloxacin isolated from pediatric patients in China / BMC Infectious
D. L. Paterson / 2000 / Recommendation for treatment of severe infections caused by enterobacteriaceae producing extended-spectrum β-lactamases / Clin Microbiol Infect 6 :
Elder JS / 2011 / Nelson textbook of pediatrics / Elsevier : 1829 ~ 1834
Eu Suk Kim, / 2014 / Clinical Importance and Epidemiology of Quinolone Resistance / Infection and Chemotherapy 46 (4) : 226 ~ 238
Aihua Wang / 2008 / Presence of qnr gene in Escherichia coli and Klebsiella pneumoniae resistant to ciprofloxacin isolated from pediatric patients in China / BMC Infectious
D. L. Paterson / 2000 / Recommendation for treatment of severe infections caused by enterobacteriaceae producing extended-spectrum β-lactamases / Clin Microbiol Infect 6 :
Elder JS / 2011 / Nelson textbook of pediatrics / Elsevier : 1829 ~ 1834
Eu Suk Kim, / 2014 / Clinical Importance and Epidemiology of Quinolone Resistance / Infection and Chemotherapy 46 (4) : 226 ~ 238
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