지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 121 - 127 (7page)
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초록· 키워드
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Purpose: The aim of this study was to determine the prevalence of antibiotic susceptibility and resistance of Escherichia coli in urinary tract infections (UTIs) in children.
Methods: We retrospectively reviewed the clinical records of 212 inpatients aged 18 years or younger with UTIs treated at the Pediatric Department of Dongguk University Gyeongju Hospital between January 2008 and December 2016. For comparison, patients were divided into three groups according to age as follows: group 1, ≤1 month; group 2, >1 month to ≤12 months; and group 3, ≥13 months.
The antibiotic resistance rates from January 2008 to December 2012 (study period 1) and from January 2013 to December 2016 (study period 2) were analyzed statistically by group.
Results: As the patient age increased, the antibiotic resistance rate to ampicillin (P =0.013), levofloxacin (P =0.050), piperacillin/tazobactam (TZP) (P <0.001), and trimethoprim/sulfamethoxazole (P =0.002) increased. The frequency of extended spectrum beta-lactamase producing E. coli showed a significant difference from 5 cases (4.6%) in study period 1 and 16 cases (15.8%) in study period 2 (P =0.007). The antibiotic resistance rate of E. coli was compared between the two time periods and we found that the antibiotic resistance rate to cefotaxime was significantly increased from 5.4% to 16.8% (P =0.008) and that to TZP was significantly decreased from 40.5% to 7.9% (P <0.001).
Conclusion: Over the past 9 years, the resistance rate to cefotaxime has increased but the resistance rate to TZP has decreased. Thus, it is important to continue to investigate the antibiotic resistance rates of bacteria in the community.
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참고문헌 (15)
참고문헌 신청
American Academy of Pediatrics Committee on Quality Improvement Subcommittee on Urinary Tract Infection / 1999 / Practice parameter : the diagnosis, treatment, and evaluation
Daza R / 2001 / Antibiotic susceptibility of bacterial strains isolated from patients with community acquired urinary tract infections / Int J Antimicrob Agents 18 : 211 ~ 2
Elder JS / 2007 / Nelson textbook of pediatrics / WB Saunders Co : 2223 ~ 2228
Khurana S / 2002 / Extended spectrum β-lactamase mediated resistance in urinary tract isolates of family Enterobacteriaceae / Indian J Med Res 116 : 145 ~ 149
Procop GW / 2003 / Cross-class resistance to non-β-lactam antimicrobials in extended-spectrum β-lactamase-producing Klebsiella pneumoniae / Am J Clin Pathol 120 : 265 ~ 26
Daza R / 2001 / Antibiotic susceptibility of bacterial strains isolated from patients with community acquired urinary tract infections / Int J Antimicrob Agents 18 : 211 ~ 2
Elder JS / 2007 / Nelson textbook of pediatrics / WB Saunders Co : 2223 ~ 2228
Khurana S / 2002 / Extended spectrum β-lactamase mediated resistance in urinary tract isolates of family Enterobacteriaceae / Indian J Med Res 116 : 145 ~ 149
Procop GW / 2003 / Cross-class resistance to non-β-lactam antimicrobials in extended-spectrum β-lactamase-producing Klebsiella pneumoniae / Am J Clin Pathol 120 : 265 ~ 26
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