지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 45 - 49 (5page)
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초록· 키워드
오류제보하기
Purpose: This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS).
Methods: Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorti coid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen pati ents were treated with GC alone and 18 were treated with GC and CsA. The cumula tive doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (Δ height Z score/year). The associa tions between linear growth and clinical parameters were analyzed.
Results: The linear growth of patients in the two groups was not significantly dif ferent (P=0.262). The Δ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumula tive dose of GC and positively correlated with the Z score for height at the time of diagnosis.
Conclusion: In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Motoyama O / 2007 / Final height in children with steroid-sensitive nephrotic syndrome / Pediatr Int 49:623~625
Gulati S / 2005 / Longitudinal follow-up of bone mineral density in children with nephrotic syndrome and the role of calcium and vitamin D supplements / Nephrol Dial Transplant 20:1598~1603
Ishikura K / 2008 / Effective and safe treatment with cyclosporine in nephrotic children : a prospective, randomized multicenter trial / Kidney Int 73:1167~1173
Ishikura K / 2012 / Two-year follow-up of a prospective clinical trial of cyclosporine for frequently relapsing nephrotic syndrome in children / Clin J Am Soc Nephrol 7:1576~1583
Freundlich M / 2006 / Bone mineral content and mineral metabolism during cyclosporine treatment of nephrotic Syndrome / J Pediatr 149:383~389
Gulati S / 2005 / Longitudinal follow-up of bone mineral density in children with nephrotic syndrome and the role of calcium and vitamin D supplements / Nephrol Dial Transplant 20:1598~1603
Ishikura K / 2008 / Effective and safe treatment with cyclosporine in nephrotic children : a prospective, randomized multicenter trial / Kidney Int 73:1167~1173
Ishikura K / 2012 / Two-year follow-up of a prospective clinical trial of cyclosporine for frequently relapsing nephrotic syndrome in children / Clin J Am Soc Nephrol 7:1576~1583
Freundlich M / 2006 / Bone mineral content and mineral metabolism during cyclosporine treatment of nephrotic Syndrome / J Pediatr 149:383~389
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스테로이드 의존성 소아 신증후군에서 Cyclosporine의 치료 효과 및 안전성
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