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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 366 - 371 (6page)
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Background/Aims: The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR.
Methods: We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers.
Results: BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive.
Conclusions: The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival.
(Clin Mol Hepatol 2016;22:366-371)
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참고문헌 (20)
참고문헌 신청
Hai-Rim Shin / 2005 / The Prevalence of Hepatitis C Virus Infection in Korea: Pooled Analysis / Journal of Korean Medical Science 20(6):985~988
Kim SJ. / 2012 / Viral hepatitis surveillance system and statue of C hepatitis sentinel surveillance in Korea :214~219
Gane EJ / 1996 / A longitudinal analysis of hepatitis C virus replication following liver transplantation / Gastroenterology 110:167~177
Howell J / 2014 / Hepatitis C recurrence: the Achilles heel of liver transplantation / Transpl Infect Dis 16:1~16
Gordon SC / 2013 / Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease / Aliment Pharmacol Ther 38:784~793
Kim SJ. / 2012 / Viral hepatitis surveillance system and statue of C hepatitis sentinel surveillance in Korea :214~219
Gane EJ / 1996 / A longitudinal analysis of hepatitis C virus replication following liver transplantation / Gastroenterology 110:167~177
Howell J / 2014 / Hepatitis C recurrence: the Achilles heel of liver transplantation / Transpl Infect Dis 16:1~16
Gordon SC / 2013 / Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease / Aliment Pharmacol Ther 38:784~793
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