지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Ever since the Korean Red Cross adopted HCV NAT for blood donor screening in 2005, HCV NAT reactive donors have been identified every year. The identification of the clinical features for these HCV NAT reactive donors may be helpful for the treatment and prevention of HCV infection. Methods: We analyzed HCV NAT reactive samples to examine the distribution of HCV RNA genotypes and the quantitative values of 128 and 47 HCV NAT reactive samples in 2007 and 2017, respectively. Results: The dominant genotype of the HCV NAT reactive donors was 1b showing 50.0% (64/128) in 2007 and 44.7% (21/47) in 2017. The genotype 2a was the second most dominant at 40.6% (52/128) in 2007 and 40.4% (19/47) in 2017. The mean titers of HCV RNA were 3.17×106 IU/mL in 2007 and 2.61×106 IU/mL in 2017. More than 90% of the donors showed a range of more than 1,000 IU/mL for the HCV RNA titer. There was no difference of quantitative values in the different genotypes. Conclusion: In this study, the distribution of HCV RNA genotypes in Korean blood donors showed a similar pattern compared to that of the general population. There was no correlation between the quantitative values and genotypes in the HCV NAT reactive blood donors, and there was no significant variation in the distribution of HCV RNA genotypes of the HCV NAT reactive donors between 2007 and 2017. Yet it is thought that the characteristics of HCV NAT reactive samples in other years have to be analyzed to achieve more significant results. (Korean J Blood Transfus 2019;30:205-211)
목차
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참고문헌 (11)
참고문헌 신청
Hajarizadeh B / 2013 / Epidemiology and natural history of HCV infection / Nat Rev Gastroenterol Hepatol 10:553~562
Sang Soo Lee / 2012 / Type and cause of liver disease in Korea: single-center experience, 2005-2010 / Clinical and Molecular Hepatology 18(3):309~315
정숙향 / 2015 / C형 간염의 역학 / 대한내과학회지 88(6):630~634
Gower E / 2014 / Global epidemiology and genotype distribution of the hepatitis C virus infection / J Hepatol 61(1 Suppl):S45~S57
Messina JP / 2015 / Global distribution and prevalence of hepatitis C virus genotypes / Hepatology 61:77~87
Sang Soo Lee / 2012 / Type and cause of liver disease in Korea: single-center experience, 2005-2010 / Clinical and Molecular Hepatology 18(3):309~315
정숙향 / 2015 / C형 간염의 역학 / 대한내과학회지 88(6):630~634
Gower E / 2014 / Global epidemiology and genotype distribution of the hepatitis C virus infection / J Hepatol 61(1 Suppl):S45~S57
Messina JP / 2015 / Global distribution and prevalence of hepatitis C virus genotypes / Hepatology 61:77~87
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