지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 372 - 381 (10page)
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Background/Aims: Chronic liver disease leads to liver fibrosis, and although the liver does have a certain regenerative capacity, this disease is associated with dysfunction of the liver vessels. C-reactive protein (CRP) is produced in the liver and circulated from there for metabolism. CRP was recently shown to inhibit angiogenesis by inducing endothelial cell dysfunction. The objective of this study was to determine the effect of CRP levels on angiogenesis in a rat model of liver dysfunction induced by bile duct ligation (BDL).
Methods: The diameter of the hepatic vein was analyzed in rat liver tissues using hematoxylin and eosin (H&E) staining. The expression levels of angiogenic factors, albumin, and CRP were analyzed by real-time PCR and Western blotting. A tube formation assay was performed to confirm the effect of CRP on angiogenesis in human umbilical vein endothelial cells (HUVECs) treated with lithocholic acid (LCA) and siRNA-CRP.
Results: The diameter of the hepatic portal vein increased significantly with the progression of cirrhosis. The expression levels of angiogenic factors were increased in the cirrhotic liver. In contrast, the expression levels of albumin and CRP were significantly lower in the liver tissue obtained from the BDL rat model than in the normal liver. The CRP level was correlated with the expression of albumin in hepatocytes treated with LCA and siRNA-CRP. Tube formation was significantly decreased in HUVECs when they were treated with LCA or a combination of LCA and siRNA-CRP.
Conclusions: CRP seems to be involved in the abnormal formation of vessels in hepatic disease, and so it could be a useful diagnostic marker for hepatic disease. (Clin Mol Hepatol 2016;22:372-381)
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참고문헌 (26)
참고문헌 신청
Bode JG / 2012 / Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling / Eur J Cell Biol 91:496~505
Kwong E / 2015 / Bile acids and sphingosine- 1-phosphate receptor 2 in hepatic lipid metabolism / Acta Pharm Sin B 5:151~157
Gaudio E / 1995 / Hepatic microcirculation as a morpho-functional basis for the metabolic zonation in normal and pathological rat liver / Ital J Anat Embryol 100(Suppl 1):419~428
Furutani Y / 2015 / Hepatic fibrosis and angiogenesis after bile duct ligation are endogenously expressed vasohibin-1 independent / Biochem Biophys Res Commun 463:384~388
Elpek GO / 2015 / Angiogenesis and liver fibrosis / World J Hepatol 7:377~391
Kwong E / 2015 / Bile acids and sphingosine- 1-phosphate receptor 2 in hepatic lipid metabolism / Acta Pharm Sin B 5:151~157
Gaudio E / 1995 / Hepatic microcirculation as a morpho-functional basis for the metabolic zonation in normal and pathological rat liver / Ital J Anat Embryol 100(Suppl 1):419~428
Furutani Y / 2015 / Hepatic fibrosis and angiogenesis after bile duct ligation are endogenously expressed vasohibin-1 independent / Biochem Biophys Res Commun 463:384~388
Elpek GO / 2015 / Angiogenesis and liver fibrosis / World J Hepatol 7:377~391
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