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논문 기본 정보
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- 학술저널
- 저자정보
- 발행연도
- 2009.1
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- 1 - 6 (6page)
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Acetylcholine (Ach) acting on the muscarinic receptors is the major stimulus for the detrusor inducing contraction if the bladder is distended and the bladder volume is at the threshold. There are 5 types muscarinic receptor subtypes cloned (M1-M5). Among them, the M2 subtype distributed dominantly in amount in the detrusor and its role seems to be primarily by blocking stimuli from cAMP-coupled receptors that induce relaxation. In contrast, through M3 receptors on the detrusor the strong contractile stimulus evoked even if its distribution in secondarily common. The excitatory M1 and inhibitory M2 and M4 subtypes are also expresswed prejunctionally. Like detrusor, urothelium also expressed all subtypes of muscarinic receptors, and on stimulation it releases factors affecting bladder afferents and smooth muscle. During inflammation, the expression of muscarinic M5 receptors is increased, particularly in the urothelium, together with a cholinergic-induced production of nitric oxide in the mucosa. This review will be discussed expression and functional effects of muscarinic receptors in the lower urinary tract. Clinical aspects of the different muscarinic receptors and roles in the pathologic conditions included in this discussions. (J Korean Continence Soc 2009;13:1-6)
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] -
Andersson KE / 2002 / Bladder activation: afferent mechanisms / Urology 59 : 43 ~ 50
Bonner TI / 1988 / Cloning and expression of the human and rat M 5 muscarinic acetylcholine receptor genes / Neuron 1 : 403 ~ 410
Casanova MF / 2006 / Regulatory mechanisms of cortical laminar development / Brain Res Rev 51 : 72 ~ 74
Chess-Williams R / 2009 / The minor population of M 3 -receptors mediate contraction of human detrusor muscle in vitro / Giglio/Tobin Pharma- cology 266 83 : 259 ~ 269
Andersson KE / 2002 / Bladder activation: afferent mechanisms / Urology 59 : 43 ~ 50
Bonner TI / 1988 / Cloning and expression of the human and rat M 5 muscarinic acetylcholine receptor genes / Neuron 1 : 403 ~ 410
Casanova MF / 2006 / Regulatory mechanisms of cortical laminar development / Brain Res Rev 51 : 72 ~ 74
Chess-Williams R / 2009 / The minor population of M 3 -receptors mediate contraction of human detrusor muscle in vitro / Giglio/Tobin Pharma- cology 266 83 : 259 ~ 269
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m2 Muscarinic Receptors Stimulate Neuronal Nitric Oxide Synthase
한국응용약물학회 춘계학술발표논문집
1996 .01
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비수기성 항 Histamine제와 대뇌 Muscarine 수용체와의 상호작용
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1999 .01
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항(抗) Histamine제(劑)와 Muscarinic Receptor와의 상호작용(相互作用)(I) -심장(心臟) muscarinic receptor에 대한 작용(作用)-
약학회지
1988 .01
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항 Histamine제와 Muscarinic Receptor와의 상호작용(II) -대뇌 Muscarinic $M_1$ Receptor에 대한 작용-
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1990 .01
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Effect of bay K 8644, A Calcium Channel Agonist, on Dog Cardiac Muscarinic Receptors
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1991 .01
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소 부신수질 Muscarine 수용체의 성질
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
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Mutation of a Transposed Amino Acid Triplet Repeat Enhances Coupling of m1 Muscarinic Receptor to Activation of Phospholipase C
한국응용약물학회 춘계학술발표논문집
1996 .01
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항 Histamine제의 $H_1$-Receptor와 Muscarinic Receptor에 대한 상대적 역가
한국응용약물학회 신약개발 연구발표회
1993 .01
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항 히스타민제의 $H_1$ 수용체와 무스카린 수용체에 대한 상대적 역가
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1993 .01
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Differential Coupling of G$\alpha$q Family of G-protein to Muscarinic $M_1$ Receptor and Neurokinin-2-Receptor
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
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The correlation of muscarinic acetylcholine 1 receptor with status epilepticus in the hippocampus
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2017 .06
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Binding affinity of some herbal extracts on the muscarinic acetylcholine receptor subtype 1 (mAChR-Ml )
대한약학회 학술대회
2001 .01
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Coupling Efficiencies of m1, m3 and m5 Muscarinic Receptors to the Stimulation of Neuronal Nitric Oxide Synthase
한국응용약물학회 춘계학술발표논문집
1996 .01
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Changes of M1 muscarinic receptor mRNA and $[^3H]$ pirenzepine receptor binding in the brain of sensitized mice by methamphetamine administration
대한약학회 학술대회
2003 .01
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The role of G protein in muscarinic receptor-mediated $\alpha$APPs release in SH-SY5Y cells
대한약학회 학술대회
2000 .01
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Digital Autoradiographic System을 이용한 Muscarinic Cholinergic Receptor의 정상쥐에서의 국소 뇌 부위별 분포
대한핵의학회 학술대회
1990 .01
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Involvement of $PLA_2$ Isoforms in Muscarinic Receptor-Mediated sAPP Release and Store-Operated Calcium Entry in SH-SY5Y Cells.
대한약학회 학술대회
2003 .01
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Interaction of Antihistaminics with Muscarinic Receptor (III) - Relationship between binding and functional in vitro data -
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1991 .01
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Tissue Specific Expression of Adrenergic Receptors and Muscarinic Receptors in Digestive Organ of Miniature Pigs
Laboratory Animal Research
2007 .09
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