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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 717 - 726 (10page)
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초록· 키워드
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Purpose: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiplerecurrences and late distant metastasis. Biological markers for assessing the prognosis of ACC have remained elusive. Thepurpose of this study was to investigate whether the protein expressions of ataxia telangiectasia mutated (ATM), p53, and ATMmediatedphosphorylated p53 are related to patient survival in ACC. Materials and Methods: In this study, 48 surgical samples were used to assess the expressions of ATM and its downstream targetp53. Fisher’s exact test and Kaplan-Meier analysis were conducted to evaluate the role of ATM, p53, and phospho-p53 (S15) proteinexpressions in predicting patient survival and distant metastasis. Results: Myb expression was positive in 85.4% of ACCs, but did not reflect patient survival rate. In contrast, low expression of ATMin cancer cells was significantly correlated with poor survival rate (p=0.037). Moreover, under positive p53 expression, low expressionof ATM was highly predictive of poor survival in ACC (p=0.017). Conclusion: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic markerfor assessing survival rate in patients with ACC of the salivary glands.
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참고문헌 (30)
참고문헌 신청
Nagao T / 2003 / Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases / Mod Pathol 16:1265~1272
Bhayani MK / 2012 / Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands / Cancer 118:2872~2878
Bell D / 2011 / Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma / Cancer Biol Ther 12:569~573
Brill LB 2nd / 2011 / Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms / Mod Pathol 24:1169~1176
West RB / 2011 / MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation / Am J Surg Pathol 35:92~99
Bhayani MK / 2012 / Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands / Cancer 118:2872~2878
Bell D / 2011 / Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma / Cancer Biol Ther 12:569~573
Brill LB 2nd / 2011 / Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms / Mod Pathol 24:1169~1176
West RB / 2011 / MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation / Am J Surg Pathol 35:92~99
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