지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,064 - 1,073 (10page)
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초록· 키워드
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Purpose Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYBNFIB oncogene fusion and Notch1 mutation have been identified in ACC, little is known about the expression and clinical significance of Notch1 and its target gene fatty acid binding protein 7 (FABP7) in tracheobronchial ACC. Materials and Methods Primary tracheobronchial ACC that were resected between 1998 and 2014 were identified through the pathology and oncology database from five thoracic oncology centers in China. A tissue array was constructed from the patients’ samples and the expressions of Notch1 and FABP7 were evaluated by immunohistochemistry. The association between the expression of both markers and survival was determined. Results Overexpression of Notch1 and FABP7, detected in 37.8% and 38.3% of 368 patients with tracheobronchial ACC, respectively, was an independent prognostic indicator for recurrencefree survival (RFS) by multivariable Cox proportional hazard model (p=0.032 and p=0.048, respectively). Overexpression of Notch1, but not of FABP7, predicted overall survival (OS) (p=0.018). When categorized into four groups according to coexpression of Notch1 and FABP7, patients with overexpression of both Notch1 and FABP7 belonged to the group with the shortest RFS and OS (p=0.01 and p=0.048, respectively). Conclusion Expression of Notch1 and FABP7, and coexpression of Notch1 and FABP7, is strongly associated with poor survival in resected tracheobronchial ACC. These data are consistent with the hypothesis that poor differentiation of tracheobronchial ACC correlates with the activation of Notch signaling.
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참고문헌 (29)
참고문헌 신청
Xu LT / 1987 / Clinical and pathologic characteristics in patients with tracheobronchial tumor: report of 50 patients / Ann Thorac Surg 43:276~278
Nomori H / 1988 / Adenoid cystic carcinoma of the trachea and mainstem bronchus: a clinical, histopathologic, and immunohistochemical study / J Thorac Cardiovasc Surg 96:271~277
Grillo HC / 1990 / Primary tracheal tumors: treatment and results / Ann Thorac Surg 49:69~77
Li N / 2012 / A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry / Cancer 118:3945~3953
Maziak DE / 1996 / Adenoid cystic carcinoma of the airway: thirty-two-year experience / J Thorac Cardiovasc Surg 112:1522~1531
Nomori H / 1988 / Adenoid cystic carcinoma of the trachea and mainstem bronchus: a clinical, histopathologic, and immunohistochemical study / J Thorac Cardiovasc Surg 96:271~277
Grillo HC / 1990 / Primary tracheal tumors: treatment and results / Ann Thorac Surg 49:69~77
Li N / 2012 / A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry / Cancer 118:3945~3953
Maziak DE / 1996 / Adenoid cystic carcinoma of the airway: thirty-two-year experience / J Thorac Cardiovasc Surg 112:1522~1531
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