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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 736 - 745 (10page)
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초록· 키워드
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Purpose: Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotectiveeffects in ischemia/reperfusion (IR) injured hearts. This study investigated the mechanism of the cardioprotective effectsof EVs derived from hypoxia-preconditioned human mesenchymal stem cells (MSCs). Materials and Methods: EV solutions (0.4 μg/μL) derived from normoxia-preconditioned MSCs (EVNM) and hypoxia-preconditionedMSCs (EVHM) were delivered in a rat IR injury model. Successful EV delivery was confirmed by the detection of PKH26staining in hearts from EV-treated rats. Results: EVHM significantly reduced infarct size (24±2% vs. 8±1%, p<0.001), and diminished arrhythmias by recovering electricalconduction, INa current, and Cx43 expression. EVHM also reversed reductions in Wnt1 and β-catenin levels and increases in GSK3βinduced after IR injury. miRNA-26a was significantly increased in EVHM, compared with EVNM, in real-time PCR. Finally, in in vitroexperiments, hypoxia-induced increases in GSK3β expression were significantly reduced by the overexpression of miRNA-26a. Conclusion: EVHM reduced IR injury by suppressing GSK3β expression via miRNA-26a and increased Cx43 expression. Thesefindings suggest that the beneficial effect of EVHM is related with Wnt signaling pathway.
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참고문헌 (40)
참고문헌 신청
Maroko PR / 1971 / Factors influencing infarct size following experimental coronary artery occlusions / Circulation 43:67~82
Reimer KA / 1977 / The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs / Circulation 56:786~794
Bolli R / 2004 / Myocardial protection at a crossroads: the need for translation into clinical therapy / Circ Res 95:125~134
Mathivanan S / 2010 / Exosomes: extracellular organelles important in intercellular communication / J Proteomics 73:1907~1920
Yellon DM / 2014 / Exosomes: nanoparticles involved in cardioprotection? / Circ Res 114:325~332
Reimer KA / 1977 / The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs / Circulation 56:786~794
Bolli R / 2004 / Myocardial protection at a crossroads: the need for translation into clinical therapy / Circ Res 95:125~134
Mathivanan S / 2010 / Exosomes: extracellular organelles important in intercellular communication / J Proteomics 73:1907~1920
Yellon DM / 2014 / Exosomes: nanoparticles involved in cardioprotection? / Circ Res 114:325~332
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