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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 157 - 165 (9page)
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ObjectiveThis study aimed to analyze the expression pattern of glycogen synthase kinase 3β (GSK3β) and its phosphorylatedforms, GSK3β phosphorylated at Ser9 (pS9GSK3β), and GSK3β phosphorylated at Tyr216 (pY216GSK3β), in cervicalsquamous cell carcinoma (SCC) and adenocarcinoma (AC). MethodsWe performed immunohistochemical staining for GSK3β, pS9GSK3β, and pY216GSK3β in 64 SCC and 20 AC cases andcompared their expression patterns between the 2 tumor types. ResultsIncreased GSK3β and pS9GSK3β expression but decreased pY216GSK3β expression compared with that in the normalcervix were observed in both SCC and AC specimens. Specifically, the levels of GSK3β and pS9GSK3β were significantlyincreased in SCC and AC, respectively. GSK3β was localized in the nucleus and/or cytoplasm of SCC and AC cells. However, pS9GSK3β was predominantly localized in the membrane of AC cells, whereas it was present in the nucleusand/or cytoplasm of SCC cells. ConclusionThe results suggest that the phosphorylation status of GSK3β changes during cervical cancer development and thedifferent expression levels and patterns of GSK3β and pS9GSK3β are associated with the specific histologic phenotypeof cervical cancer.
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참고문헌 (34)
참고문헌 신청
Wang SS / 2004 / Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000 / Cancer 100:1035~1044
Green J / 2003 / Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years : the UK National Case-Control Study of Cervical Cancer / Br J Cancer 89:2078~2086
Bertelsen BI / 2006 / Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia : frequent PIK3CA amplification and AKT phosphorylation / Int J Cancer 118:1877~1883
Pett MR / 2004 / Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes / Cancer Res 64:1359~1368
Duensing S / 2003 / Centrosomes, genomic instability, and cervical carcinogenesis / Crit Rev Eukaryot Gene Expr 13:9~23
Green J / 2003 / Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years : the UK National Case-Control Study of Cervical Cancer / Br J Cancer 89:2078~2086
Bertelsen BI / 2006 / Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia : frequent PIK3CA amplification and AKT phosphorylation / Int J Cancer 118:1877~1883
Pett MR / 2004 / Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes / Cancer Res 64:1359~1368
Duensing S / 2003 / Centrosomes, genomic instability, and cervical carcinogenesis / Crit Rev Eukaryot Gene Expr 13:9~23
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