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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 322 - 330 (9page)
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The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors involved have been extensively studied in the past ten years. Recent studies have elucidated the important role of chromatin remodeling and epigenetic changes for proper regulation of gene expression of lineage-specific cytokines. These include DNA methylation and histone modifications in epigenomic reprogramming during T helper cell development and effector T cell functions. This review discusses the basic epigenetic mechanisms and the role of transcription factors for the differential cytokine gene regulation in the T helper lymphocyte subsets.
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참고문헌 (27)
참고문헌 신청
Abbas AK / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Afkarian M / 2002 / T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells / Nat Immunol 3 : 549 ~ 557
Ansel KM / 2003 / An epigenetic view of helper T cell differentiation / Nat Immunol 4 : 616 ~ 623
Hsieh CS / 1993 / Development of TH1 CD4 + T cells through IL-12 produced by Listeria-induced macrophages / Science 260 : 547 ~ 549
Ivanov, II / 2006 / The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells / Cell 126 : 1121 ~ 1133
Afkarian M / 2002 / T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells / Nat Immunol 3 : 549 ~ 557
Ansel KM / 2003 / An epigenetic view of helper T cell differentiation / Nat Immunol 4 : 616 ~ 623
Hsieh CS / 1993 / Development of TH1 CD4 + T cells through IL-12 produced by Listeria-induced macrophages / Science 260 : 547 ~ 549
Ivanov, II / 2006 / The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells / Cell 126 : 1121 ~ 1133
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