지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 482 - 489 (8page)
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초록· 키워드
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Purpose: This study attempted to derive an objective and sophisticated definition of poor ovarian response (POR). Materials and Methods: A total of 176 consecutive in vitro fertilization (IVF) cycles (137 patients) with conventional ovarian stimulationduring 2009 to 2012 were studied by retrospective analysis. Optimal oocyte number (total or mature) was determined by statistics-based (distribution of oocyte number) and prognosis-based approaches (prediction for IVF outcome). Receiver operating characteristics curve analysis was used to show what number of oocytes could predict IVF pregnancy and whether clinical and laboratory variables could predict newly defined POR. Results: The 25th percentile of the distribution correspondedto total oocytes ≤2 and mature oocyte ≤1. The cut-off values for the predictionof IVF outcomes were total oocytes >5 and mature oocyte >1. Considering the incidence of POR (34.1%), a reasonable definition of POR was decided as total oocytes≤2 or mature oocyte ≤1. For the prediction of this new definition, the extreme cut-off value (by setting a false positive rate of 5%) of serum anti-Mullerian hormone(AMH) was ≤0.76 ng/mL, which was better than serum follicle stimulating hormone or age. A new simple definition of POR was derived as total oocytes ≤2 or mature oocyte ≤1 in a previous cycle or a serum AMH level of ≤0.76 ng/mL. When this simple criterion was re-applied to our data, the predictive performance was similarto the Bologna criteria. Conclusion: We here propose a new definition of POR, which is simple and supported by statistical and prognostic analyses.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ebner T / 2006 / Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles / Hum Reprod 21 : 2022 ~ 2026
Elgindy EA / 2008 / Anti-Mullerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm
Ferraretti AP / 2011 / ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria / Hum Reprod 26 : 1616 ~
Ficicioglu C / 2006 / Early follicular antimullerian hormone as an indicator of ovarian reserve / Fertil Steril 85 : 592 ~ 596
Frydman R / 2011 / Poor responders : still a problem / Fertil Steril 96 : 1057 ~
Elgindy EA / 2008 / Anti-Mullerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm
Ferraretti AP / 2011 / ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria / Hum Reprod 26 : 1616 ~
Ficicioglu C / 2006 / Early follicular antimullerian hormone as an indicator of ovarian reserve / Fertil Steril 85 : 592 ~ 596
Frydman R / 2011 / Poor responders : still a problem / Fertil Steril 96 : 1057 ~
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