Association between decreased ovarian reserve and poor oocyte quality

Viviane Margareth Scantamburlo; Renate von Linsingen; Lidio Jair Ribas Centa; Kahisa Fontana Dal Toso; Debora Scaraboto; Edward Araujo Júnior; Jaime Kulak Junior

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자료유형: 학술저널

저자정보: Viviane Margareth Scantamburlo (Human Reproduction and Andrology Clinic and Laboratory) Renate von Linsingen (Human Reproduction and Andrology Clinic and Laboratory) Lidio Jair Ribas Centa (Human Reproduction and Andrology Clinic and Laboratory) Kahisa Fontana Dal Toso (Human Reproduction and Andrology Clinic and Laboratory) Debora Scaraboto (Human Reproduction and Andrology Clinic and Laboratory) Edward Araujo Júnior (Federal University of São Paulo (EPM-UNIFESP)) Jaime Kulak Junior (Federal University of Paraná (UFPR))

저널정보: 대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제64권 제6호

발행연도: 2021.11

수록면: 532 - 539 (8page)

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ObjectiveTo analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young womenundergoing controlled ovarian stimulation (COS). MethodsThis retrospective study included 49 patients classified as having DOR based on anti-Mullerian hormone (AMH)levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocyteswere analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilizedgonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. TheStudent’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated toverify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate theassociation between patient- and oocyte-related variables, logistic regression models were adjusted. ResultsWomen with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DORaccording to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according toAFC had an increased risk of abnormally shaped oocytes (P=0.035). ConclusionThis study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes inyoung women who underwent COS.

#Infertility #Oocyte quality #Ovarian reserve #Controlled ovarian stimulation #Decreased ovarian reserve

참고문헌 (21)

참고문헌 신청

American College of Obstetricians / 2014 / Female age-related fertility decline. Committee Opinion No. 589 / Fertil Steril 101:633~634

Wallace WH / 2010 / Human ovarian reserve from conception to the menopause / PLoS One 5:e8772

Practice Committee of the American Society for Reproductive Medicine / 2015 / Testing and interpreting measures of ovarian reserve: a committee opinion / Fertil Steril 103:e9~e17

European Society of Human Reproduction and Embryology / Management of women with premature ovarian insufficiency. Guideline of the european society of human reproduction and embryology

Tarasconi B / 2017 / Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer / Fertil Steril 108:518~524

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