지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 634 - 640 (7page)
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초록· 키워드
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Purpose: The BRAFV600E mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of free circulating mutant BRAFV600E in predicting the advanced disease of PTC. Materials and Methods: Seventy seven matched tumor and plasma samples obtained from patients with both benign and PTC were analyzed for BRAFV600E mutation using a peptide nucleic acid (PNA) clamp real-time polymerase chain reaction (PCR). Results: The BRAFV600E mutationwas absent in tumor DNA samples obtained from patients with benign follicularadenomas or adenomatous goiter. In contrast, 49 of 72 (68.1%) PTC tumors were positive for the BRAFV600E mutation. Among them, 3 (6.1%) patients with PTC were positive for BRAFV600E mutation in plasma and tumor. However, all 3 patients(100%) had lateral lymph node and lung metastasis. Conclusion: These findingssuggest that the BRAFV600E mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis. Future studies are warranted to determine clinical significance of serum BRAFV600E mutation in large prospective studies.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benbassat CA / 2006 / Clinicopathological characteristics and long-term outcome in patients with distant metastases from differentiated thyroid cancer / World J Surg 30 : 108
Chuang TC / 2010 / Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas / Head Neck 32 : 229 ~ 234
Cradic KW / 2009 / Mutant BRAF(T1799A) can be detected in the blood of papillary thyroid carcinoma patients and correlates with disease status / J Clin Endocrinol Metab 94 :
Elisei R / 2008 / BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study / J Clin Endocrinol Metab 93 : 3943 ~ 3949
Grebe SK / 1996 / Thyroid cancer nodal metastases: biologic significance and therapeutic considerations / Surg Oncol Clin N Am 5 : 43 ~ 63
Chuang TC / 2010 / Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas / Head Neck 32 : 229 ~ 234
Cradic KW / 2009 / Mutant BRAF(T1799A) can be detected in the blood of papillary thyroid carcinoma patients and correlates with disease status / J Clin Endocrinol Metab 94 :
Elisei R / 2008 / BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study / J Clin Endocrinol Metab 93 : 3943 ~ 3949
Grebe SK / 1996 / Thyroid cancer nodal metastases: biologic significance and therapeutic considerations / Surg Oncol Clin N Am 5 : 43 ~ 63
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Contralateral Central Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma with Ipsilateral Lateral Neck Metastasis
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Association Between <sup>18</sup>F-FDG Avidity and the BRAF Mutation in Papillary Thyroid Carcinoma
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Active and Passive Smoking, BRAFV600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study
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Nomogram for predicting central lymph node metastasis in papillary thyroid carcinoma
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The Clinical Significance of the BRAF Mutation in Patients with Papillary Thyroid Cancer
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BRAFV600E Mutation is a Strong Preoperative Indicator for Predicting Malignancy in Thyroid Nodule Patients with Atypia of Undetermined Significance Identified by Fine Needle Aspiration
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The BRAF<sup>T1799A</sup> Mutation is not Associated with Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma
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Evaluation of the VE1 Antibody in Thyroid Cytology Using Ex Vivo Papillary Thyroid Carcinoma Specimens
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Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells
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