Association between BRAFV600E Mutations and Clinicopathological Features of Papillary Thyroid Microcarcinoma (PTMC)

Sung Min Lee; 이초록; 강상욱; 이잔디; 정종주; 남기현; 정웅윤; 박정수

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자료유형: 학술저널

저자정보: Sung Min Lee 이초록 강상욱 이잔디 정종주 남기현 정웅윤 박정수

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제19권 제3호

발행연도: 2019.1

수록면: 76 - 84 (9page)

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Purpose: In this study, the relationship between the BRAFV600E mutation and the clinicopathological features of papillary thyroid microcarcinoma (PTMC) was examined in a single center. Methods: From January 2011 to December 2012, a total of 911 patients with PTMC who underwent thyroidectomy at Severance Hospital, Korea were enrolled in this study. The status of BRAFV600E mutation was assessed in thyroid fine-needle aspiration specimens by real-time polymerase chain reaction amplification prior to thyroidectomy. The associations between BRAFV600E mutation status and clinicopathological features of PTMC were examined. Results: The overall prevalence of the BRAFV600E mutations was 78.8% (717/911). Chi-square analysis revealed that BRAFV600E mutations were significantly associated with the male sex, lateral neck node metastasis, and several risk factors. And the age, tumor size, extent of surgery, multiplicity, bilaterality, central node metastasis, and distant metastasis were not associated with BRAFV600E mutation. Multivariate analysis showed that capsular invasion and lateral neck node metastasis were significantly associated with BRAFV600E mutations. In particular, lateral neck node metastasis showed negative correlation with BRAFV600E mutations. And the recurrence rate and disease-free survival were not associated with BRAFV600E mutation status. Conclusion: BRAFV600E mutations in PTMC was associated with presence of capsular invasion and absence of lateral neck node metastasis. However, BRAFV600E mutations could not serve as a prognostic factor that affected the recurrence of PTMC in our study.

참고문헌 (33)

참고문헌 신청

DeLellis RA / 2004 / Pathology and Genetics of Tumours of Endocrine Organs / International Agency for Research on Cancer (IARC)

Roti E / 2008 / Thyroid papillary microcarcinoma : a descriptive and meta-analysis study / Eur J Endocrinol 159:659~673

Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133

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송영신 / 2015 / Mutation Profile of Well-Differentiated Thyroid Cancer in Asians / Endocrinology and Metabolism 30(3):252~262

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