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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 819 - 824 (6page)
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Purpose: This study aims to investigate the additive effect of the Hedera helix (HH) and Rhizoma coptidis (RC) extracts mixture on antitussive and expectorant activities in animals. Materials and Methods: The expectorant assay was performedwith phenol red secretion in mice trachea. Mice or guinea pigs were randomlydivided into groups of 8 each, including negative and positive control groups. After gastric administration of the test extracts in mice, 2.5% phenol red solution (0.2 mL) was intraperitoneally injected. Trachea was dissected and optical density of tracheal secretion was measured. After gastric administration of the test extracts in guinea pigs, the antitussive activities were assessed using a citric acid-induced cough measurement. Results: The extracts of HH and RC significantly increased tracheal secretion and inhibited cough. The mixture of HH and RC extractsin a 1:1 concentration at a dose of 200 mg/kg showed a more potent effect on phenol red secretion (25.25±3.14) and cough inhibition (61.25±5.36) than the individual use of each extracts [phenol red secretion; HH 13.39±4.22 (p=0.000), RC 20.78±2.50 (p=0.010), cough inhibition; HH 9.89±4.14 (p=0.010), RC 30.25± 7.69 (p=0.000)]. A 3:1 ratio mixture of HH to RC demonstrated an optimal expectoranteffect (p<0.001), and this mixture showed expectorant and antitussive effectsin a dose-dependent manner. Conclusion: This study provides evidence for antitussive and expectorant effect of a 3:1 mixture of HH and RC, which may be a useful therapeutic option for respiratory diseases.
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참고문헌 (22)
참고문헌 신청
CHOI, UNG-KYU / 2007 / Optimization of Antibacterial Activity by Gold-Thread (Coptidis RhizomaFranch) Against Streptococcus mutans Using Evolutionary Operation-FactorialDesi
Cioaca C / 1978 / The saponins of Hedera helix with antibacterial activity / Pharmazie 33 : 609 ~ 610
Donaldson SH / 2006 / Mucus clearance and lung function in cystic fibrosis with hypertonic saline / N Engl J Med 354 : 241 ~ 250
Engler H / 1984 / Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds / J Pharmacol Methods 11 : 151 ~ 157
Holzinger F / 2011 / Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections / Evid Based Com
Cioaca C / 1978 / The saponins of Hedera helix with antibacterial activity / Pharmazie 33 : 609 ~ 610
Donaldson SH / 2006 / Mucus clearance and lung function in cystic fibrosis with hypertonic saline / N Engl J Med 354 : 241 ~ 250
Engler H / 1984 / Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds / J Pharmacol Methods 11 : 151 ~ 157
Holzinger F / 2011 / Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections / Evid Based Com
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