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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 144 - 151 (8page)
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초록· 키워드
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Alopecia has emerged as one of the biggest interests in modern society. Many studies have focused on the treatment of alopecia, such as transplantation of hair follicles or inhibition of the androgen pathway. Hair growth is achieved through proper proliferation of the components such as keratinocytes and dermal papilla cells (DPCs), movement, and interaction between the two cells. The present study examined the effect of the hedgehog (Hh) signaling pathway, which is an important and fundamental signal in the cell, on the morphology and the viability of human keratinocytes and DPCs. Upregulation of Hh signaling caused a morphological change and an increase in epithelium-mesenchymal transition-related gene expression but reduced the viability of keratinocytes, while the alteration of Hh signaling did not cause any change in DPCs. The results show the possibility that the regulation of Hh signaling can be applied for the treatment of alopecia.
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참고문헌 (39)
참고문헌 신청
Aniketh Venkataram / 2018 / Logic of hair transplantation / Journal of Cutaneous and Aesthetic Surgery 11(4):169~172
ROBERT M. BERNSTEIN / 1997 / Follicular Transplantation / Dermatologic Surgery 23(9):771~784
Andy Goren / 2018 / Minoxidil in the treatment of androgenetic alopecia / Dermatologic Therapy 31(5):e12686
Julian Mackay-Wiggan / 2016 / Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata / JCI Insight 1(15):e89790
STEPHEN D. WHITE / 1995 / Resident Dendritic Cells in the Epidermis: Langerhans Cells, Merkel Cells and Melanocytes / Veterinary Dermatology 6(1):1~8
ROBERT M. BERNSTEIN / 1997 / Follicular Transplantation / Dermatologic Surgery 23(9):771~784
Andy Goren / 2018 / Minoxidil in the treatment of androgenetic alopecia / Dermatologic Therapy 31(5):e12686
Julian Mackay-Wiggan / 2016 / Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata / JCI Insight 1(15):e89790
STEPHEN D. WHITE / 1995 / Resident Dendritic Cells in the Epidermis: Langerhans Cells, Merkel Cells and Melanocytes / Veterinary Dermatology 6(1):1~8
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