지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,361 - 1,369 (9page)
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초록· 키워드
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Purpose: The objective of this study was to develop a new nomogram that can predict 28-day mortality in severe sepsis and/or septic shock patients using a combination of several biomarkers that are inexpensive and readily available in most emergency departments, with and without scoring systems.
Materials and Methods: We enrolled 561 patients who were admitted to an emergency department (ED) and received early goal-directed therapy for severe sepsis or septic shock. We collected demographic data, initial vital signs, and laboratory data sampled at the time of ED admission. Patients were randomly assigned to a training set or validation set. For the training set, we generated models using independent variables associated with 28-day mortality by multivariate analysis, and developed a new nomogram for the prediction of 28-day mortality. Thereafter, the diagnostic accuracy of the nomogram was tested using the validation set.
Results: The prediction model that included albumin, base excess, and respiratory rate demonstrated the largest area under the receiver operating characteristic curve (AUC) value of 0.8173 [95% confidence interval (CI), 0.7605–0.8741]. The logistic analysis revealed that a conventional scoring system was not associated with 28-day mortality. In the validation set, the discrimination of a newly developed nomogram was also good, with an AUC value of 0.7537 (95% CI, 0.6563–0.8512).
Conclusion: Our new nomogram is valuable in predicting the 28-day mortality of patients with severe sepsis and/or septic shock in the emergency department. Moreover, our readily available nomogram is superior to conventional scoring systems in predictingmortality.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Zimmerman JE / 2013 / Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012 / Crit Care 17:R81
Angus DC / 2013 / Severe sepsis and septic shock / N Engl J Med 369:840~851
Miller RR 3rd / 2013 / Multicenter implementation of a severe sepsis and septic shock treatment bundle / Am J Respir Crit Care Med 188:77~82
Kaukonen KM / 2014 / Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012 / JAMA 311:1308~1316
Martin GS / 2003 / The epidemiology of sepsis in the United States from 1979 through 2000 / N Engl J Med 348:1546~1554
Angus DC / 2013 / Severe sepsis and septic shock / N Engl J Med 369:840~851
Miller RR 3rd / 2013 / Multicenter implementation of a severe sepsis and septic shock treatment bundle / Am J Respir Crit Care Med 188:77~82
Kaukonen KM / 2014 / Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012 / JAMA 311:1308~1316
Martin GS / 2003 / The epidemiology of sepsis in the United States from 1979 through 2000 / N Engl J Med 348:1546~1554
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