지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,206 - 1,212 (7page)
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초록· 키워드
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Purpose: To investigate predictors of progression to castration-resistant prostate cancer (CRPC) and cancer-specific mortality (CSM) in patients with metastatic prostate cancer (mPCa).
Materials and Methods: A retrospective analysis was performed on 440 consecutive treatment-naïve patients initially diagnosed with mPCa between August 2000 and June 2012. Patient age, body mass index (BMI), Gleason score, prostate-specific antigen (PSA), PSA nadir, American Joint Committee on Cancer stage, Visual Analogue Scale pain score, Eastern Cooperative Oncology Group performancescore (ECOG PS), PSA response to hormone therapy, and metastatic sites were assessed. Cox-proportional hazards regressionanalyses were used to evaluate survivals and predictive variables of men with bone metastasis stratified according to the presenceof pain, compared to men with visceral metastasis.
Results: Metastases were most often found in bone (75.4%), followed by lung (16.3%) and liver (8.3%) tissues. Bone metastasis, pain, and high BMI were associated with increased risks of progression to CRPC, and bone metastasis, pain, PSA nadir, and ECOG PS≥1 were significant predictors of CSM. During the median follow-up of 32.0 (interquartile range 14.7–55.9) months, patients with bone metastasis with pain and patients with both bone and visceral metastases showed the worst median progression to CRPC-free and cancer-specific survivals, followed by men with bone metastasis without pain. Patients with visceral metastasis had the best median survivals.
Conclusion: Metastatic spread and pain patterns confer different prognosis in patients with mPCa. Bone may serve as a crucial microenvironment in the development of CRPC and disease progression.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Achbarou A / 1994 / Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo / Cancer Res 54 : 2372 ~ 2377
Chodak GW / 1991 / Independent prognostic factors in patients with metastatic (stage D2) prostate cancer. The Zoladex Study Group / JAMA 265 : 618 ~ 621
Coleman RE / 2006 / Clinical features of metastatic bone disease and risk of skeletal morbidity / Clin Cancer Res 12 (20 Pt 2) : 6243s ~ 6249s
Cooperberg MR / 2009 / Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis / J Natl Cancer Inst 101 : 878 ~ 887
Corn PG. / 2012 / The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development / Cancer Manag Res 4 : 183 ~ 193
Chodak GW / 1991 / Independent prognostic factors in patients with metastatic (stage D2) prostate cancer. The Zoladex Study Group / JAMA 265 : 618 ~ 621
Coleman RE / 2006 / Clinical features of metastatic bone disease and risk of skeletal morbidity / Clin Cancer Res 12 (20 Pt 2) : 6243s ~ 6249s
Cooperberg MR / 2009 / Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis / J Natl Cancer Inst 101 : 878 ~ 887
Corn PG. / 2012 / The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development / Cancer Manag Res 4 : 183 ~ 193
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