지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 368 - 374 (7page)
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Purpose: To investigate the relationship between rising patterns of prostate-specific antigen (PSA) before chemotherapy and PSA flare during the early phase of chemotherapyin patients with castration-resistant prostate cancer (CRPC). Materials and Methods: This study included 55 patients with CRPC who received chemotherapy and in whom pre-treatment or post-treatment PSA levels could be serially obtained. The baseline parameters included age, performance, Gleason score, PSA level, and disease extent. PSA doubling time was calculated using the different intervals: the conventional interval from the second hormone manipulation following the nadir until anti-androgen withdrawal (PSADT1), the interval from the initial rise after anti-androgen withdrawal to the start of chemotherapy (PSADT2), and the interval from the nadir until the start of chemotherapy (PSADT3). The PSA growth patterns were analyzed using the ratio of PSADT2 to PSADT1. Results: There were two growth patterns of PSA doubling time: 22 patients (40.0%) had a steady pattern with a more prolonged PSADT2 than PSADT1, while 33 (60.0%) had an accelerating pattern with a shorter PSADT2 than PSADT1. During three cycles of chemotherapy,PSA flare occurred in 11 patients (20.0%); of these patients, 3 were among 33 (9.1%) patients with an accelerating PSA growth pattern and 8 were among 22 patients(36.4%) with a steady PSA growth pattern (p=0.019). Multivariate analysis showed that only PSA growth pattern was an independent predictor of PSA flare (p=0.034). Conclusion: An exponential rise in PSA during anti-androgen withdrawalis a significant predictor for PSA flare during chemotherapy in CRPC patients.
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참고문헌 (20)
참고문헌 신청
Arlen PM / 2008 / Prostate Specific Antigen Working Group guidelines on prostate specific antigen doubling time / J Urol 179 : 2181 ~ 2185
Armstrong AJ / 2009 / Using surrogate biomarkers to predict clinical benefit in men with castration-resistant prostate cancer: an update and review of the literature / Oncolo
Daskivich TJ / 2006 / Prostate specific antigen doubling time calculation: not as easy as 1, 2, 4 / J Urol 176 : 1927 ~ 1937
Debes JD / 2004 / Mechanisms of androgen-refractory prostate cancer / N Engl J Med 351 : 1488 ~ 1490
Fossa SD / 2002 / Liposomal doxorubicin (Caelyx) in symptomatic androgen-independent prostate cancer (AIPC)--delayed response and flare phenomenon should be considered / Sca
Armstrong AJ / 2009 / Using surrogate biomarkers to predict clinical benefit in men with castration-resistant prostate cancer: an update and review of the literature / Oncolo
Daskivich TJ / 2006 / Prostate specific antigen doubling time calculation: not as easy as 1, 2, 4 / J Urol 176 : 1927 ~ 1937
Debes JD / 2004 / Mechanisms of androgen-refractory prostate cancer / N Engl J Med 351 : 1488 ~ 1490
Fossa SD / 2002 / Liposomal doxorubicin (Caelyx) in symptomatic androgen-independent prostate cancer (AIPC)--delayed response and flare phenomenon should be considered / Sca
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