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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 981 - 987 (7page)
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Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients.
Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed.
Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies.
Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling,and in two patients, the lesions were detected after 3 years by means of 68Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging.
Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.
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참고문헌 (24)
참고문헌 신청
Agrawal K / 2015 / Comparison of 18F-FDG and 68Ga DOTATATE PET/CT in localization of tumor causing oncogenic osteomalacia / Clin Nucl Med 40 : e6 ~ e10
Andreopoulou P / 2011 / Cutler Peck CM, Wodajo FM, et al. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors / J Bone Miner Res 26 : 12
Chong WH / 2011 / Tumor-induced osteomalacia / Endocr Relat Cancer 18 : R53 ~ R77
Dupond JL / 2005 / Oncogenic osteomalacia: diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET/CT scan for the diagnosis and follow-up in on
Folpe AL / 2004 / Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature /
Andreopoulou P / 2011 / Cutler Peck CM, Wodajo FM, et al. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors / J Bone Miner Res 26 : 12
Chong WH / 2011 / Tumor-induced osteomalacia / Endocr Relat Cancer 18 : R53 ~ R77
Dupond JL / 2005 / Oncogenic osteomalacia: diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET/CT scan for the diagnosis and follow-up in on
Folpe AL / 2004 / Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature /
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