지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 294 - 302 (9page)
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Purpose: We investigated whether red blood cell distribution width (RDW) predicts vasculitis activity based on Birmingham vasculitisactivity score (BVAS) or BVAS for granulomatosis with polyangiitis (GPA) at diagnosis and poor prognosis during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Materials and Methods: We reviewed the medical records of 150 patients with AAV. We defined severe GPA as BVAS for GPA ≥7 (the highest quartile). Correlation and standardised correlation coefficients were analysed by linear regression tests. The differences between groups were evaluated by Mann-Whitney test. Relative risk (RR) was assessed by chi square test and Cox hazards model. Results: RDW was correlated only with the vasculitis activity of GPA among patients with AAV. An increase in RDW was associatedwith the absence of ear nose throat (ENT) manifestation, but not proteinase 3-ANCA. Significant differences were noted in cumulativerefractory free survival according to RDW ≥15.4% (p=0.007) and the absence of ENT manifestation (p=0.036). MultivariateCox hazards analysis identified RDW ≥15.4% as the only significant predictor of refractory disease in GPA (RR 17.573). Conclusion: RDW predicts vasculitis activity in GPA, and RDW ≥15.4% at diagnosis may increase the risk of severe GPA at diagnosisand predict refractory diseases during follow-up.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Bloch DA / 1990 / The American College of Rheumatology 1990 criteria for the classification of vasculitis. Patients and methods / Arthritis Rheum 33:1068~1073
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Leavitt RY / 1990 / The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis / Arthritis Rheum 33:1101~1107
Masi AT / 1990 / The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) / Arthritis Rheum 33:1094~1100
Bloch DA / 1990 / The American College of Rheumatology 1990 criteria for the classification of vasculitis. Patients and methods / Arthritis Rheum 33:1068~1073
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Leavitt RY / 1990 / The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis / Arthritis Rheum 33:1101~1107
Masi AT / 1990 / The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) / Arthritis Rheum 33:1094~1100
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