지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 24 - 30 (7page)
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초록· 키워드
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Purpose: To analyze treatment outcome and side effects of adjuvant radiotherapy using radiotherapy fields and doses which have evolved over the last two decades in a single institution. Materials and Methods: Forty-one patients received radiotherapyafter orchiectomy from 1996 to 2007. At our institution, the treatment field for stage I seminoma has changed from dog-leg (DL) field prior to 2003 to paraaortic (PA) field after 2003. Fifteen patients were treated with the classic fractionation scheme of 25.5 Gy at 1.5 Gy per fraction. Other patients had been treated with modifiedschedules of 25.05 Gy at 1.67 Gy per fraction (n=15) and 25.2 Gy at 1.8 Gy per fraction (n=11). Results: With a median follow-up of 112 months, the 5-year and 10-year survival rates were 100% and 96%, respectively, and 5-year and 10-year relapse-free survival rates were both 97.1%. No in-field recurrence occurred. Contralateral seminoma occurred in one patient 5 years after treatment. No grade III‒IV acute toxicity occurred. An increased rate of grade 1‒2 acute hematologic toxicity was found in patients with longer overall treatment times due to 1.5 Gy per fraction. The rate of grade 2 acute gastrointestinal toxicity was significantly higher with DL field than with PA field and also higher in the 1.8-Gy group than in the 1.5-Gy and 1.67-Gy groups. Conclusion: Patients with stage I seminoma were safely treated with PA-only radiotherapy with no pelvic failure. Optimal fractionation schedule needs to be explored further in order to minimize treatment-related toxicity.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Fossa SD / 1999 / Optimal planning target volume for stage I testicular seminoma: a Medical Research Council randomized trial. Medical Research Council Testicular Tumor Work
Girinsky T / 2007 / Radiotherapy of hodgkin lymphoma: indications, new fields, and techniques / Semin Radiat Oncol 17 : 206 ~ 222
Gordon W Jr / 1997 / A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711) / Int J Radiat Oncol Biol Phys 38 : 8
Groll RJ / 2007 / A comprehensive systematic review of testicular germ cell tumor surveillance / Crit Rev Oncol Hematol 64 : 182 ~ 197
Huyghe E / 2003 / Increasing incidence of testicular cancer worldwide: a review / J Urol 170 : 5 ~ 11
Girinsky T / 2007 / Radiotherapy of hodgkin lymphoma: indications, new fields, and techniques / Semin Radiat Oncol 17 : 206 ~ 222
Gordon W Jr / 1997 / A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711) / Int J Radiat Oncol Biol Phys 38 : 8
Groll RJ / 2007 / A comprehensive systematic review of testicular germ cell tumor surveillance / Crit Rev Oncol Hematol 64 : 182 ~ 197
Huyghe E / 2003 / Increasing incidence of testicular cancer worldwide: a review / J Urol 170 : 5 ~ 11
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