지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 82 - 88 (7page)
이용수
이 논문의 연구 히스토리 (3)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Purpose: The expression of p53 in patients with rectal cancer who underwent preoperativechemoradiationand and its potential prognostic significance were evaluated.
Materials and Methods: p53 expression was examined using immunohistochemistryin pathologic specimens from 210 rectal cancer patients with preoperative chemoradiotherapy and radical surgery. All patients were classified into two groups according to the p53 expression: low p53 (<50% nuclear staining) and high p53 (≥50%) groups. Results: p53 expression was significantly associated with tumorlocation from the anal verge (p=0.036). In univariate analysis, p53 expression was not associated with disease-free survival (p=0.118) or local recurrence-free survival (p=0.089). Multivariate analysis showed that tumor distance from the anal verge (p=0.006), ypN category (p=0.011), and perineural invasion (p=0.048) were independent predictors of disease-free survival; tumor distance from the anal verge was the only independent predictor of local recurrence-free survival. When the p53 groups were subdivided according to ypTNM category, disease-free survival differed significantly in patients with ypN+ disease (p=0.027) only. Conclusion: Expression of p53 in pathologic specimens as measured by immunohistochemical methods may have a significant prognostic impact on survival in patients with ypN+ rectal cancer with preoperative chemoradiotherapy. However, it was not an independent predictor of recurrence or survival.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bouzourene H / 2000 / p53 and Ki-ras as prognostic factors for Dukes’ stage B colorectal cancer / Eur J Cancer 36 : 1008 ~ 1015
Garcia-Aguilar J / 2003 / A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patie
Habr-Gama A / 2005 / Long-term results of preoperative chemoradiation for distal rectal cancer correlation between final stage and survival / J Gastrointest Surg 9 : 90 ~ 99
Hendriks Y / 2003 / Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors / Am J Pathol 162 : 469 ~ 4
Huh JW / 2008 / Accuracy of endorectal ultrasonography and computed tomography for restaging rectal cancer after preoperative chemoradiation / J Am Coll Surg 207 : 7 ~ 12
Garcia-Aguilar J / 2003 / A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patie
Habr-Gama A / 2005 / Long-term results of preoperative chemoradiation for distal rectal cancer correlation between final stage and survival / J Gastrointest Surg 9 : 90 ~ 99
Hendriks Y / 2003 / Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors / Am J Pathol 162 : 469 ~ 4
Huh JW / 2008 / Accuracy of endorectal ultrasonography and computed tomography for restaging rectal cancer after preoperative chemoradiation / J Am Coll Surg 207 : 7 ~ 12
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prognostic Factors and Treatment of Recurrence after Local Excision of Rectal Cancer
Yonsei Medical Journal
2021 .12
-
Preoperative chemoradiation for locally advanced rectal cancer: comparison of three radiation dose and fractionation schedules
Radiation oncology journal : ROJ
2016 .01
-
What are the most important prognostic factors in patients with residual rectal cancer after preoperative chemoradiotherapy?
영남의대학술지
2019 .01
-
Long-term Oncologic Outcome and Its Relevant Factors in Anal Cancer in Korea: A Nationwide Data Analysis
Annals of Coloproctology
2020 .01
-
Impact of Time Interval Between Chemoradiation and Surgery on Pathological Complete Response and Survival in Rectal Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer
Radiation oncology journal : ROJ
2016 .01
-
Impact of Adjuvant Therapy Type on Survival in Stage II/III Rectal Cancer Without Preoperative Chemoradiation: A Korean Multicenter Retrospective Study
Annals of Coloproctology
2018 .01
-
Characteristics and Survival of Korean Patients With Colorectal Cancer Based on Data From the Korea Central Cancer Registry Data
Annals of Coloproctology
2018 .01
-
Impact of circumferential tumor location of mid to low rectal cancer on oncologic outcomes after preoperative chemoradiotherapy
Annals of Surgical Treatment and Research
2022 .08
-
What are the most important prognostic factors in patients with residual rectal cancer after preoperative chemoradiotherapy?
Journal of Yeungnam Medical Science
2019 .01
-
Chemotherapeutic Response and Survival for Patients With an Anal Squamous Cell Carcinoma and Low Hemoglobin Levels
Annals of Coloproctology
2018 .01
-
Initial local excision for clinical T1 rectal cancer showed comparable overall survival despite high local recurrence rate: a propensity-matched analysis
Annals of Coloproctology
2022 .04
-
Association between Metformin Use and Survival in Nonmetastatic Rectal Cancer Treated with a Curative Resection: A Nationwide Population Study
Cancer Research and Treatment
2017 .01
-
Effect of time interval between capecitabine intake and radiotherapy on local recurrence-free survival in preoperative chemoradiation for locally advanced rectal cancer
Radiation oncology journal : ROJ
2017 .01
-
원발성 외이도암의 재발 양상
대한 두경부 종양 학술지
2017 .01
-
Is Late Recurrence need to be More Alert in Rectal Cancer Patients treated with Preoperative Chemoradiotherapy?
대한외과학회 학술대회 초록집
2019 .10
-
Using the Lymph Node Ratio to Evaluate the Prognosis of Stage II/III Breast Cancer Patients Who Received Neoadjuvant Chemotherapy and Mastectomy
Cancer Research and Treatment
2015 .01
-
Tumor Diameter for Prediction of Recurrence, Disease Free and Overall Survival in Endometrial Cancer Cases
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Oncologic outcomes in rectal cancer with close distal resection margins : a retrospective analysis
Annals of Surgical Treatment and Research
2015 .06
-
Predictors of Permanent Stoma in Mid or Low Rectal Cancer Patients : Result of a Multicenter Prospective Cohort Including Preoperative Anal Function
대한외과학회 학술대회 초록집
2018 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0