지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 879 - 884 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations betweenthe ALDH2 polymorphism and the risk of ALC.
Materials and Methods: Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databasesup to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model.
Results: A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphismwas associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61–0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations.
Conclusion: The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Rehm J / 2009 / Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders / Lancet 373:2223~2233
O’Shea RS / 2010 / Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease / Hepatology 51:307~328
Monzoni A / 2001 / Genetic determinants of ethanol-induced liver damage / Mol Med 7:255~262
Stickel F / 2012 / Genetic determinants of alcoholic liver disease / Gut 61:150~159
Yoshida A / 1998 / Human aldehyde dehydrogenase gene family / Eur J Biochem 251:549~557
O’Shea RS / 2010 / Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease / Hepatology 51:307~328
Monzoni A / 2001 / Genetic determinants of ethanol-induced liver damage / Mol Med 7:255~262
Stickel F / 2012 / Genetic determinants of alcoholic liver disease / Gut 61:150~159
Yoshida A / 1998 / Human aldehyde dehydrogenase gene family / Eur J Biochem 251:549~557
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect Modification of Acetaldehyde Dehydrogenase 2 rs671 Polymorphism on the Association between Alcohol Intake and Blood Pressure: the Dong-gu Study
Journal of Korean Medical Science
2020 .01
-
Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
Yonsei Medical Journal
2017 .07
-
ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment
Clinical Psychopharmacology and Neuroscience
2020 .01
-
Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
A Detailed Analysis of Alcohol Pharmacokinetics in Healthy Korean Men
대한법의학회지
2015 .01
-
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer
Journal of Breast Cancer
2015 .01
-
Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Association with Corneal Remodeling Related Genes, ALDH3A1, LOX, and SPARC Genes Variations in Korean Keratoconus Patients
Korean Journal of Ophthalmology
2021 .01
-
Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans
Cancer Research and Treatment
2021 .01
-
Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients
Clinical and Molecular Hepatology
2021 .01
-
A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial for Efficacy of Acetyl-L-carnitine in Patients with Dementia Associated with Cerebrovascular Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2018 .01
-
IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis
Yonsei Medical Journal
2015 .01
-
Patients with Liver Cirrhosis
대한외과학회 학술대회 초록집
2021 .11
-
랫드에서 Aldehyde Dehydrogenase Related Compounds의 알콜 및 알데히드 분해 효능평가
한국환경보건학회지
2023 .04
-
Matrix Metalloproteinase-2 -1306 C>T Gene Polymorphism is Associated with Reduced Risk of Cancer: a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
G894T and 4a/b Polymorphisms of NOS3 Gene are Not Associated with Cancer Risk: a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Enhanced cinnamaldehyde cytotoxicity via oxidative stress through inhibition of aldehyde dehydrogenase activity in breast cancer cell lines
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea
Clinical and Molecular Hepatology
2020 .01
-
An analysis of polygenic risk scores for non-alcoholic fatty liver disease
Clinical and Molecular Hepatology
2021 .01
-
The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients
Cancer Research and Treatment
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0