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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 489 - 496 (8page)
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초록· 키워드
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Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate a special transcriptional program that renders them more aggressive biologicalbehaviors. Hypoxia-inducible factors (HIFs) are the key factors that control hypoxia-inducible pathways by regulating the expression of a vast array of genes involved in cancer progression and treatment resistance. HIFs, mainly HIF-1 and -2, have becomepotential targets for developing novel cancer therapeutics. This article reviews the updated information in tumor HIF pathways,particularly recent advances in the development of HIF inhibitors. These inhibitors interfere with mRNA expression, proteinsynthesis, protein degradation and dimerization, DNA binding and transcriptional activity of HIF-1 and -2, or both. Despite efforts in the past two decades, no agents directly inhibiting HIFs have been approved for treating cancer patients. By analyzing results of the published reports, we put the perspectives at the end of the article. The therapeutic efficacy of HIF inhibitors may be improved if more efforts are devoted on developing agents that are able to simultaneously target HIF-1 and -2, increasing the penetrating capacity of HIF inhibitors, and selecting suitable patient subpopulations for clinical trials.
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참고문헌 (26)
참고문헌 신청
Agnieszka Loboda / 2010 / HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical / Molecules and Cells 29 (5) : 435 ~ 442
Bertout JA / 2008 / The impact of O2 availability on human cancer / Nat Rev Cancer 8 : 967 ~ 975
Bruick RK / 2001 / A conserved family of prolyl-4-hydroxylases that modify HIF / Science 294 : 1337 ~ 1340
Duan C / 2016 / Hypoxia-inducible factor 3 biology: complexities and emerging themes / Am J Physiol Cell Physiol 310 : C260 ~ C269
Gu YZ / 1998 / Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha / Gene Expr 7 : 205 ~ 213
Bertout JA / 2008 / The impact of O2 availability on human cancer / Nat Rev Cancer 8 : 967 ~ 975
Bruick RK / 2001 / A conserved family of prolyl-4-hydroxylases that modify HIF / Science 294 : 1337 ~ 1340
Duan C / 2016 / Hypoxia-inducible factor 3 biology: complexities and emerging themes / Am J Physiol Cell Physiol 310 : C260 ~ C269
Gu YZ / 1998 / Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha / Gene Expr 7 : 205 ~ 213
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