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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,678 - 1,685 (8page)
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Purpose: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelialgrowth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and on experimental choroidal neovascularization(CNV) in mice.
Materials and Methods: ARPE-19 cells were treated with different concentrations of resveratrol and then incubated under hypoxicconditions with subsequent evaluation of cell viability, expression of HIF-1α, and expression of VEGF. The effects of resveratrolon the synthesis and degradation of hypoxia-induced HIF-1α were evaluated using inhibitors of the PI3K/Akt/mTOR and theubiquitin proteasome pathways. In animal studies, CNV lesions were induced in C57BL/6 mice by laser photocoagulation. After 7days of oral administration of resveratrol or vehicle, which began one day after CNV induction, image analysis was used to measureCNV areas on choroidal flat mounts stained with isolectin IB4.
Results: In ARPE-19 cells, resveratrol significantly inhibited HIF-1α and VEGF in a dose-dependent manner, by blocking thePI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1α degradation. In mice experiments, orally administeredresveratrol significantly inhibited CNV growth in a dose-dependent manner.
Conclusion: Resveratrol may have therapeutic value in the management of diseases involving pathological neovascularization.
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참고문헌 (24)
참고문헌 신청
Balaiya S / 2013 / Res
Baur JA / 2006 / Resveratrol improves health and survival of mice on a high-calorie diet / Nature 444 : 337 ~ 342
Brown DM / 2006 / Ranibizumab versus verteporfin for neovascular age-related macular degeneration / N Engl J Med 355 : 1432 ~ 1444
Cao Z / 2004 / trans-3,4,5’-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells / Cli
Chung EJ / 2009 / Inhibition of choroidal neovascularisation in mice by systemic administration of the multikinase inhibitor, sorafenib / Br J Ophthalmol 93 : 958 ~ 963
Baur JA / 2006 / Resveratrol improves health and survival of mice on a high-calorie diet / Nature 444 : 337 ~ 342
Brown DM / 2006 / Ranibizumab versus verteporfin for neovascular age-related macular degeneration / N Engl J Med 355 : 1432 ~ 1444
Cao Z / 2004 / trans-3,4,5’-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells / Cli
Chung EJ / 2009 / Inhibition of choroidal neovascularisation in mice by systemic administration of the multikinase inhibitor, sorafenib / Br J Ophthalmol 93 : 958 ~ 963
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