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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 557 - 563 (7page)
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초록· 키워드
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Purpose: The aim of this study is to investigate the molecular characteristics of occult hepatitis B virus (HBV) infection in ‘anti-HBc alone’ subjects.
Materials and Methods: Twenty-four patients with ‘anti-HBc alone’ and 20 control patients diagnosed with HBV were analyzed regardingS and pre-S gene mutations. All specimens were analyzed for HBs Ag, anti-HBc, and anti-HBs. For specimens with an anti-HBc alone, quantitative analysis of HBV DNA, as well as sequencing and mutation analysis of S and pre-S genes, were performed.
Results: A total 24 were analyzed for the S gene, and 14 were analyzed for the pre-S gene through sequencing. A total of 20 control patients were analyzed for S and pre-S gene simultaneously. Nineteen point mutations of the major hydrophilic region were found in six of 24 patients. Among them, three mutations, S114T, P127S/T, M133T, were detected in common. Only one mutation was found in five subjects of the control group; this mutation was not found in the occult HBV infection group, however. Pre-S mutations were detected in 10 patients, and mutations of site aa58–aa100 were detected in 9 patients. A mutation on D114E was simultaneouslydetected. Although five mutations from the control group were found at the same location (aa58–aa100), no mutations of occult HBV infection were detected.
Conclusion: The prevalence of occult HBV infection is not low among ‘anti-HBc alone’ subjects. Variable mutations in the S gene and pre-S gene were associated with the occurrence of occult HBV infection. Further larger scale studies are required to determinethe significance of newly detected mutations.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행
Allain JP / 2009 / Characterization of occult hepatitis B virus strains in South African blood donors / Hepatology 49 : 1868 ~ 1876
Candotti D / 2012 / Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence / Gut 61 : 1744 ~ 17
Chen CH / 2009 / A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular
Coleman PF / 1999 / Immunoassay detection of hepatitis B surface antigen mutants / J Med Virol 59 : 19 ~ 24
Allain JP / 2009 / Characterization of occult hepatitis B virus strains in South African blood donors / Hepatology 49 : 1868 ~ 1876
Candotti D / 2012 / Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence / Gut 61 : 1744 ~ 17
Chen CH / 2009 / A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular
Coleman PF / 1999 / Immunoassay detection of hepatitis B surface antigen mutants / J Med Virol 59 : 19 ~ 24
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