지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 506 - 527 (22page)
이용수
초록· 키워드
오류제보하기
Purpose C5α receptor 1 (C5ΑR1) is associated with the development of various human cancers. However, whether it is involved in the development of hepatitis B virus (HBV)?related hepatocellular carcinoma (HCC) is poorly understood. We explored the expression, biological role, and associated mechanisms of C5AR1 in HBV-related hepatoma cells. Materials and Methods The expression of C5ΑR1 mediated by HBV and HBV core protein (HBc) was detected in hepatoma cells. The function of nuclear factor кB (NF-κB) pathway in HBc-induced C5AR1 expression was assessed. The roles of C5ΑR1 in the activation of intracellular signal pathways, the upregulation of inflammatory cytokines, and the growth and migration of hepatoma cells mediated by HBc, were investigated. The effect of C5α in the development of HCC mediated by C5AR1 was also measured. Results C5ΑR1 expression was increased in HBV-positive hepatoma cells. Dependent on HBc, HBV enhanced the expression of C5ΑR1 at the mRNA and protein levels. Besides, HBc could promote C5ΑR1 expression via the NF-κB pathway. Based on the C5ΑR1, HBc facilitated the activation of JNK and ERK pathways and the expression and secretion of interleukin-6 in hepatoma cells. Furthermore, C5ΑR1 was responsible for enhancing the growth and migration of hepatoma cells mediated by HBc. Except these, C5α could promote the malignant development of HBc-positive HCC via C5AR1. Conclusion We provide new insight into the mechanisms of hepatocarcinogenesis mediated by HBc. C5ΑR1 has a significant role in the functional abnormality of hepatoma cells mediated by HBc, and might be utilized as a potential therapeutic target for HBV-related HCC.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Xu W / 2017 / Mechanism and prediction of HCC development in HBV infection / Best Pract Res Clin Gastroenterol 31:291~298
Wu CC / 2018 / Hepatitis B virus infection : defective surface antigen expression and pathogenesis / World J Gastroenterol 24:3488~3499
Diab A / 2018 / The diverse functions of the hepatitis B core/capsid protein(HBc)in the viral life cycle : implications for the development of HBc-targeting antivirals / Antiviral Res 149:211~220
Gai X / 2013 / Hepatitis B virus core protein enhances human telomerase reverse transcriptase expression and hepatocellular carcinoma cell proliferation in a c-Ets2-dependent manner / Int J Biochem Cell Biol 45:1174~1185
Liu W / 2018 / Hepatitis B virus core protein promotes hepatocarcinogenesis by enhancing Src expression and activating the Src/PI3K/Akt pathway / FASEB J 32:3033~3046
Wu CC / 2018 / Hepatitis B virus infection : defective surface antigen expression and pathogenesis / World J Gastroenterol 24:3488~3499
Diab A / 2018 / The diverse functions of the hepatitis B core/capsid protein(HBc)in the viral life cycle : implications for the development of HBc-targeting antivirals / Antiviral Res 149:211~220
Gai X / 2013 / Hepatitis B virus core protein enhances human telomerase reverse transcriptase expression and hepatocellular carcinoma cell proliferation in a c-Ets2-dependent manner / Int J Biochem Cell Biol 45:1174~1185
Liu W / 2018 / Hepatitis B virus core protein promotes hepatocarcinogenesis by enhancing Src expression and activating the Src/PI3K/Akt pathway / FASEB J 32:3033~3046
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma
Cancer Research and Treatment
2018 .01
-
Risk of Hepatitis B Virus (HBV) Reactivation in HBsAg-Negative, Anti-HBc-Negative Patients Receiving Rituximab for Autoimmune Diseases in HBV Endemic Areas
Gut and Liver
2023 .03
-
Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene
Yonsei Medical Journal
2017 .01
-
Prevalence of Hepatitis B Virus (HBV) Among Blood Donors in Eastern Saudi Arabia: Results From a Five-Year Retrospective Study of HBV Seromarkers
Annals of Laboratory Medicine
2019 .01
-
Safety of Tocilizumab in Rheumatoid Arthritis Patients with Resolved Hepatitis B Virus Infection: Data from Real-World Experience
Yonsei Medical Journal
2018 .01
-
MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF-κB-Inducing Kinase
Yonsei Medical Journal
2020 .01
-
Changing etiology and epidemiology of hepatocellular carcinoma: Asia and worldwide
Journal of Liver Cancer
2024 .03
-
Analysis on Postoperative Efficacy of Radical Hepatectomy for Patients with Non-HBV/HCV Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
5일 전부터 지속되는 황달
대한내과학회지
2024 .06
-
Prevalence of Hepatitis B Virus and HIV Co-infection in Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
New biomarkers of hepatitis B virus (HBV) infection: HBV RNA and HBV core-related antigen, new kids on the block?
Clinical and Molecular Hepatology
2023 .01
-
Nuclear Expression of Hepatitis B Virus X Protein Is Associated with Recurrence of Early-Stage Hepatocellular Carcinomas: Role of Viral Protein in Tumor Recurrence
Journal of Pathology and Translational Medicine
2016 .01
-
Evidence of infection with hepatitis B virus-like agent in pigs
예방수의학회지
2015 .09
-
Hepatitis B vaccination and immunotherapies: an update
Clinical and Experimental Vaccine Research
2020 .01
-
Rapid HBV DNA Undetection: Useful Marker in Predicting Tumor Recurrence after Hepatectomy for HBV-related Hepatocellular Carcinoma
대한외과학회 학술대회 초록집
2022 .05
-
High-dose tenofovir is not effective in suppressing hepatitis B virus replication in patients with hepatocellular carcinoma progression : a preliminary result
Annals of Hepato-Biliary-Pancreatic Surgery
2016 .02
-
B형 및 D형 간염바이러스 수용체
대한내과학회지
2015 .01
-
Health Screening among HBV Carriers in the Korean National Health and Nutrition Examination Survey V (KNHANES V)
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Current Trends and Recent Advances in Diagnosis, Therapy, and Prevention of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction
Clinical and Molecular Hepatology
2024 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0