지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 27 - 37 (11page)
이용수
초록· 키워드
오류제보하기
Background and Objective
Psoriasis is a chronic skin disease characterized by angiogenesis. It has been reported that growth factor as vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-II are overexpressed in psoriatic epidermis. This stydy was carried out for whether SB extracts have an anti-angiogenic effect for angiogenic factor.
Method
To investigate the inhibitory effect of VEGF expression by the SB extracts, we performed MTS assay, western blots using HaCaT cells. HaCaT cells were pretreated with SB extracts for 1 hour followed by treatment with IGF-Ⅱ.
Result
SB extracts significantly reduced IGF-II induced HIF-1α protein level via p53 and MAPK pathway in HaCaT cells. Also, SB extracts inhibited IGF-II induced VEGF mRNA and protein expression levels in the HaCaT keratinocytes.
Conclusion
These results suggest that inhibition of HIF-1α and VEGF expressions by SB extracts contributes to the anti-angiogenic effects.
Key Words : Scutellaria baicalensis, IGF-II, HIF-1α, VEGF, Psoriasis, HaCaT cells
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
/ / Banda MJ. Secretion of metalloproteinases by stimulated capillary endothelialcells. I. 한방안이비인후피부과학회지 제20권 제1호 36Expression of collagenase and stromelysi
/ / Folkman J. Tumor dormacy in vivo by prevention of neovascularization. J Exp Med 1992 : 261 ~ 276
/ / Polverini PJ. Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am J Pathol. 1994 : 820 ~ 8
/ / Powel DR. Structural and biological characterization of bovine insulin-like growth factor binding-3. Endocrinol. 1990 : 2795 ~ 2803
/ / a potent inhibitor of endothelial cel growth in vitro is angiogenic in vivo. Proc Natl Acad Sci USA 1987 : 5277 ~ 81
/ / Folkman J. Tumor dormacy in vivo by prevention of neovascularization. J Exp Med 1992 : 261 ~ 276
/ / Polverini PJ. Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am J Pathol. 1994 : 820 ~ 8
/ / Powel DR. Structural and biological characterization of bovine insulin-like growth factor binding-3. Endocrinol. 1990 : 2795 ~ 2803
/ / a potent inhibitor of endothelial cel growth in vitro is angiogenic in vivo. Proc Natl Acad Sci USA 1987 : 5277 ~ 81
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MG-63 세포주에서 Vascular Endothelial Growth Factor (VEGF) mRNA 발현에 대한Insulin-like Growth Factor I (IGF-I)의 효과에 대한 연구
대한구강악안면외과학회지
2005 .01
-
乾漆이 혈관신생관련 단백질 발현에 미치는 영향
한방안이비인후피부과학회지
2006 .01
-
The Clinicopathological Significance of Tissue Levels of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor in Gastric Cancer
Gut and Liver
2009 .01
-
生地黃이 혈관신생, 세포생존 및 염증관련 단백질발현에 미치는 영향
한방안이비인후피부과학회지
2006 .01
-
골절 치유 과정에서 HIF-1α와 VEGF의 발현
대한정형외과학회지
2008 .08
-
지부자(地膚子)의 신생혈관 및 염증매개 단백질 발현에 미치는 영향
동의생리병리학회지
2006 .01
-
비용 조직에서 Hypoxia-Inducible Factor 1α의 발현 및 Vascular Endothelial Growth Factor와의 상관관계
대한이비인후-두경부외과학회지
2004 .01
-
The Effects of Insulin-like Growth Factor-I (IGF-I) in Mouse Lung Cancer Cells
Cancer Research and Treatment
2002 .01
-
자궁목의 병기 I과 II 편평세포암종에서 Hypoxia-inducible Factor-1α 단백의 발현 : p53 단백 및 VEGF 발현과의 관련성
Journal of Pathology and Translational Medicine
2003 .01
-
The Production IL-21 and VEGF in UVB-irradiated Human Keratinocyte Cell Line, HaCaT
Immune Network
2010 .04
-
Insulin-like Growth Factor Systems의 생식기능에서의 역할;자궁편
대한불임학회잡지
1996 .01
-
Predictive Significance of VEGF and HIF-1α Expression in Patients with Metastatic Colorectal Cancer Receiving Chemotherapy Combinations with Bevacizumab
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Expression of Vascular Endothelial Growth Factors A, C and D in GastricAdenocarcinoma
Journal of Pathology and Translational Medicine
2005 .01
-
Prognostic Effect of Vascular Endothelial Growth Factor and Angiogenesis in Gastric Carcinoma
Cancer Research and Treatment
2003 .01
-
비소세포폐암주에서 저산소상태에 의해 유발된 HIFa-1 α와 VEGF의 발현증가에 미치는 Epigallocatechin-3-gallate의 억제 효과
Tuberculosis and Respiratory Diseases
2009 .01
-
No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer
Cancer Research and Treatment
2009 .01
-
VEGF-VEGFR Signals in Health and Disease
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
한국 소아 및 청소년에서 혈중 유리 insulin-like growth factor-I 농도치와 임상적 의의
Clinical and Experimental Pediatrics
2008 .01
-
사람 난소발생에 있어서 IGF2 유전자의 역할
해부·생물인류학
1996 .12
-
월경 주기에 따른 IGF-I과 -II의 혈중농도와 난소에서의 발현
Obstetrics & Gynecology Science
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0