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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 88 - 94 (7page)
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Background/Aims: Hypoxia-inducible factor-1α (HIF-
1α) is a mediator of tumor progression. Vascular endothelial
growth factor (VEGF) is the most potent angiogenic
factor known to be induced by HIF-1α. We
investigated the clinicopathological significance of
HIF-1α and VEGF levels in biopsied gastric cancer
tissue. Methods: Endoscopic biopsy specimens from
67 patients with gastric carcinoma who underwent surgery
were available for this study. Semiquantitative
RT-PCR was applied to biopsied tumors and normal
tissues to determine the expressions of HIF-1α and
VEGF. The expression levels of HIF-1α and VEGF
were evaluated using the tumor:normal (T/N) ratios of
HIF-1α and VEGF mRNA. The clinicopathological variables
were reviewed retrospectively. Results: The T/N
ratios of HIF-1α mRNA showed significant correlation
with lymph-node metastases, distant metastases,
stage, and recurrence within 3 years (p＜0.05). The
T/N ratios of VEGF mRNA showed significant correlation
with lymph-node metastases and distant metastases
(p＜0.05). There was a significant correlation
between the T/N ratios of HIF-1α and VEGF mRNA
(r=0.72, p＜0.01). Conclusions: The increased expression
of HIF-1α and VEGF mRNA could reflect
aggressive tumor behavior, including the recurrence of
gastric cancer. Examination of HIF-1α mRNA in biopsy
specimens by RT-PCR assay might provide useful
preoperative information on tumor aggressiveness.
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참고문헌 (23)
참고문헌 신청
Aoyagi K / 2005 / VEGF significance in peritoneal recurrence from gastric cancer / Gastric Cancer 8 : 155 ~ 163
Carmeliet P / 1998 / Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis / Nature 394 : 485 ~ 490
Chen WT / 2005 / Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor / Jpn J Clin Oncol 3
Fukuda R / 2003 / Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1 / Cancer Res
Griffiths EA / 2007 / Hypoxiainducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro- oesopha
Carmeliet P / 1998 / Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis / Nature 394 : 485 ~ 490
Chen WT / 2005 / Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor / Jpn J Clin Oncol 3
Fukuda R / 2003 / Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1 / Cancer Res
Griffiths EA / 2007 / Hypoxiainducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro- oesopha
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