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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 129 - 136 (8page)
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Objectives: The crude extracts of Scutellaria barbata D.
Don (SB) have traditionally demonstrated inhibitory effects on numerous human cancers both in vitro and in vivo. Gastric cancer is one of the most common types of cancer on world. The authors investigated the effects of an ethanol extract of Scutellaria barbata D. Don (ESB) on the growth and survival of MKN-45 cells (a human gastric adenocarcinoma cell line).
Methods: The MKN-45 cells were treated with different concentrations of ESB, and cell death was examined using an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Analyses of sub-G1 peaks, caspase-3 and -9 activities, and mitochondrial membrane depolarizations were conducted to determine the anti-cancer effects of SB on MKN-45 cells.
Also, intracellular reactive oxygen species (ROS) generation was investigated.
Results: ESB inhibited the growth of MKN-45 cells, caused cell cycle arrest, and increased the sub-G1 population.
In addition, ESB markedly increased mitochondrial membrane depolarization and the activities of caspase-3 and -9. ESB exerted anti-proliferative effects on MKN-45 cells by modulating the mitogen-activated protein kinase (MAPK) signaling pathway and by increasing the generation of ROS. Furthermore, combinations of anti-cancer drugs plus ESB suppressed cell growth more than treatments with an agent or ESB, and this was especially true for cisplatin, etoposide, and doxorubicin.
Conclusion: ESB has a dose-dependent cytotoxic effect on MKN-45 cells and this is closely associated with the induction of apoptosis. ESB-induced apoptosis is mediated by mitochondria- , caspase- and MAPK dependent pathways. In addition, ESB enhances ROS generation and increases the chemosensitivity of MKN-45 cells. These results suggest that treatment with ESB can inhibit the proliferation and promote the apoptosis of human gastric adenocarcinoma cells by modulating the caspase-, MAPK- and ROS-dependent pathway.
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참고문헌 (27)
참고문헌 신청
Coccolini F / 2016 / Advanced gastric cancer : what we know and what we still have to learn / World J Gastroenterol 22(3):1139~1159
Jiang Q / 2015 / Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells / Exp Ther Med 10(4):1602~1608
Wei L / 2011 / Don induces apoptosis of human colon carcinoma cell through activation of the mitochondrion dependent pathway / J Med Plant Res 5(10):1962~1970
Lin J / 2014 / Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of multiple signaling pathways / Integr Cancer Ther 13(3):240~248
Gong T / 2015 / Inhibition of tumor growth and immunomodulatory effects of flavonoids and scutebarbatines of Scutellaria barbata D. Don in lewis-bearing C57BL/6 Mice / Evid Based Complement Alternat Med 2015
Jiang Q / 2015 / Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells / Exp Ther Med 10(4):1602~1608
Wei L / 2011 / Don induces apoptosis of human colon carcinoma cell through activation of the mitochondrion dependent pathway / J Med Plant Res 5(10):1962~1970
Lin J / 2014 / Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of multiple signaling pathways / Integr Cancer Ther 13(3):240~248
Gong T / 2015 / Inhibition of tumor growth and immunomodulatory effects of flavonoids and scutebarbatines of Scutellaria barbata D. Don in lewis-bearing C57BL/6 Mice / Evid Based Complement Alternat Med 2015
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