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자료유형
학술저널
저자정보
저널정보
대한임상신경생리학회 Annals of Clinical Neurophysiology Annals of Clinical Neurophysiology 제3권 제2호
발행연도
2001.1
수록면
136 - 142 (7page)

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Background : Nervous system dysfunction is a major complication of end stage renal disease. Although severe neurologic symptoms are partially or complete reversed by adequate hemodialysis, even optimally dialyzed patients will usually not return to normal neurocognitive function. To investigate the influence of chronic renal failure and hemodialysis on higher cognitive function electrophysiologically, we studied auditory P300 event-related potentials in 14 hemodialysis patients and 14 age- and sex-matched normal healthy controls. Methods : The subjects consisted of 14 patients(M:6, F:8) with chronic renal failure(CRF) for 1 to 10 years and 14 age-and sex-matched healthy controls(M:5. F:9). For the reliability of study, patients with diabetes mellitus, abnormal brain CT findings, or low mini-mental state score(below 20) were excluded. Event related potentials(ERPs) for hemodialysis patients were performed at pre-and post-hemodialysis. To obtain ERPs, subjects underwent 2-tone auditory discrimination test(oddball paradigm). Results : Although the age(control: 48.79?0.31 years, CRF: 51.21?.61 years) and mini-mental state score(control: 27.00?.71 points, predialysis CRF: 25.07?.58 points) were not different in normal control and CRF groups significantly(P>0.05), P300 latencies at Cz(controls: 288.11?7.36 msec, predialysis CRF: 332.35?2.34 msec) were significantly delayed(P<0.05) and the duration of Trail making test A was significantly prolonged(control: 64.2?4.2 sec, CRF: 118.9?01 sec) in CRF group, P300 latencies between pre-and post-hemodialysis CRF patients(predialysis CRF: 332.35?2.34 msec, postdialysis CRF: 325.82?8.69 msec) were not significantly different. The P300 latency was not related with the duration of CRF(Spearman's correlation test, r=0.25, p>0.05) and tthe frequency of hemodialysis(Spearman's correlation test, r=0.28, P>0.05). Conclusions : From these results, we suggest that P300 latency is valuable in evaluating cognitive brain dysfunction in patients with CRF and hemodialysis does not have a significant effect on cognitive brain dysfunction in patients with CRF.

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