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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 153 - 160 (8page)
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Purpose: The aim of this study is to examine the tolerability and effect of early highdose amino acid administration in extremely low birth weight infants (ELBWIs). Methods: This retrospective cohort study included ELBWI (birth weight <1,000 g, n=142). Biochemical, nutritional, and neurodevelopmental data were compared between infants who received conventional low amino acid (LAA; 1.5 g/kg/day) and those who received high amino acid (HAA; 3 g/kg/day) within the first 48 hours after birth. Neurodevelopmental data included weight, height, and head circumference at discharge, 12 to 14 and 18 to 24 months of corrected age and the Korean Bayley Scale of Infant Development II (K-BSID-II) score at 18 to 24 months of corrected age. Results: The HAA group demonstrated higher peak plasma albumin (3.0±0.4 vs. 3.2± 0.5, P<0.05) and lower serum creatinine (1.7±0.9 vs. 1.4±0.8, P<0.05) during the first 14 days than the LAA group. Full enteral feeding was achieved significantly earlier in infants in the HAA group than in infants in the LAA group (46.2±23.0 days vs. 34.3±21 days, P<0.01). There was no difference between the two groups in the z score changes in all growth indicators from birth to discharge and at 12 to 14 and 18 to 24 months of corrected age, as well as in the K-BSID-II score at 18 to 24 months of corrected age. Conclusion: Aggressive administration of amino acids during the first 2 days of life in ELBWI was well tolerated and correlated with earlier full enteral feeding, but did not improve growth and neurodevelopment.
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참고문헌 (49)
참고문헌 신청
Ziegler EE / 1976 / Body composition of the reference fetus / Growth 40:329~341
Yang S / 2013 / Effect of high vs standard early parenteral amino acid supplementation on the growth outcomes in very low birth weight infants / JPEN J Parenter Enteral Nutr 37:327~334
Ziegler EE / 2007 / Protein requirements of very low birth weight infants / J Pediatr Gastroenterol Nutr 45(Suppl 3):S170~S174
Brownlee KG / 1993 / Early or late parenteral nutrition for the sick preterm infant / Arch Dis Child 69:281~283
Ho MY / 2003 / Early versus late nutrition support in premature neonates with respiratory distress syndrome / Nutrition 19:257~260
Yang S / 2013 / Effect of high vs standard early parenteral amino acid supplementation on the growth outcomes in very low birth weight infants / JPEN J Parenter Enteral Nutr 37:327~334
Ziegler EE / 2007 / Protein requirements of very low birth weight infants / J Pediatr Gastroenterol Nutr 45(Suppl 3):S170~S174
Brownlee KG / 1993 / Early or late parenteral nutrition for the sick preterm infant / Arch Dis Child 69:281~283
Ho MY / 2003 / Early versus late nutrition support in premature neonates with respiratory distress syndrome / Nutrition 19:257~260
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