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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 53 - 61 (9page)
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초록· 키워드
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Aspiration of meconium produces a syndrome (Meconium Aspiration Syndrome MAS) characterized by hypoxia, hypercapnia, and acidosis. Perinatal hypoxia, acute airway obstruction, pulmonary inflammation, pulmonary vasoconstriction, pulmonary hypertension, and surfactant inactivation all play a role in the pathogenesis of MAS. Most aspiration of meconium probably occurs before birth. Following aspiration, meconium may migrate to the peripheral airway, usually take about 2 hours as demonstrated in animal experiment, leading to airway obstruction and subsequent lung inflammation and pulmonary hypertension. The presence of meconium in the endotracheal aspirate automatically establishes the diagnosis of MAS. Clinical diagnosis can be made in any infant born with meconium staining of amniotic fluid who develops respiratory distress at or shortly after birth and has positive radiographic findings. Prevention of intrauterine hypoxia, early cleaning (suctioning) of the airway, and prevention and treatment of pulmonary hypertension are essential in the management of MAS. Recent studies suggest that avoidance of post-term delivery may reduce the risk of intrauterine hypoxia and the incidence of MAS. Routine intrapartum naso-and oropharyngeal suction does not appear to affect the incidence and outcome of MAS. Endotracheal suction at birth is considered a controversial procedure and only reserved for infants who have severe retraction at birth suggesting an upper airway obstruction. High frequency oscillatory ventilation with nitric oxide or surfactant may improve mortality. Mortality of MAS has improved; the causes of death are related primarily to hypoxic respiratory failure associated with irreversible pulmonary hypertension. Morbidity is affected mostly by perinatal hypoxia.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Americam Academy of Pediatrics / / Neonatal Resuscitation Program®
Carson BS / 1976 / Combined obstetric and pediatric approach to prevent meconium aspiration syndrome / Am J Obstet Gynecol 126 : 712 ~ 715
Cleary GM / 1998 / Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update / Pediatr Clin North Am 45 : 511 ~ 529
Cote RH / 1976 / Isolation, composition and reactivity of the neutral glycoproteins from human meconiums with specificities of the ABO and Lewis systems / Biochem J 153 : 63
Dargaville PA / 2006 / The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome / Pediatrics 117 : 1712 ~ 1721
Carson BS / 1976 / Combined obstetric and pediatric approach to prevent meconium aspiration syndrome / Am J Obstet Gynecol 126 : 712 ~ 715
Cleary GM / 1998 / Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update / Pediatr Clin North Am 45 : 511 ~ 529
Cote RH / 1976 / Isolation, composition and reactivity of the neutral glycoproteins from human meconiums with specificities of the ABO and Lewis systems / Biochem J 153 : 63
Dargaville PA / 2006 / The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome / Pediatrics 117 : 1712 ~ 1721
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