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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 198 - 202 (5page)
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초록· 키워드
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Purpose: The prevalence of antibiotics resistant bacterial infection among preterm infants has been increased due to indeliberate use of prophylactic broad spectrum antibiotics. The objective of this study was to assess the effectiveness of restricted usage of prophylactic antibiotics by comparing the incidence of culture proven early onset sepsis (EOS).
Methods: This was a retrospective cohort study for extremely low birth weight infants who were born in Seoul National University Children’s Hospital during 2009-2014. The groups were divided into two periods, from 2009 to 2011 (period I) and from 2012 to 2014 (period II) based on the implementation on quality improvement activity since 2012. The indication of prophylactic antibiotics were; 1) umbilical vein catheter (UVC) insertion for resuscitation in delivery room, 2) prolonged preterm premature rupture of membrane >18 hours, 3) maternal fever during labor or sustained septic amniotic fluid. The incidence of EOS and the rate of empirical antibiotics usage were compared between two periods.
Results: A total of 245 infants were admitted to the neonatal intensive care unit during the study period. Baseline demographics and clinical characteristics were similar between two periods except UVC insertion rate. The rate of empirical antibio- tics usage significantly decreased in period II (71.1% for period I vs. 56.4% for period 2, P=0.022). Incidence of EOS was not different between two periods whether pro- phylactic antibiotics use or not.
Conclusion: Quality improvement for reducing prophylactic antibiotics use may be effective to reduce a use of antibiotics without increasing EOS.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Stoll BJ / 2002 / Late-onset sepsis in very low birth weight neonates:the experience of the NICHD Neonatal Research Network / Pediatrics 110:285~291
Stoll BJ / 2004 / Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection / JAMA 292:2357~2365
Heo JS / 2015 / Neonatal sepsis in a rapidly growing, tertiary neonatal intensive care unit: trends over 18 years / Pediatr Int 57:909~916
Stoll BJ / 1996 / Early-onset sepsis in very low birth weight neonates:a report from the National Institute of Child Health and Human Development Neonatal Research Network / J Pediatrics 129:72~80
Stoll BJ / 2002 / Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants / N Engl J Med 347:240~247
Stoll BJ / 2004 / Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection / JAMA 292:2357~2365
Heo JS / 2015 / Neonatal sepsis in a rapidly growing, tertiary neonatal intensive care unit: trends over 18 years / Pediatr Int 57:909~916
Stoll BJ / 1996 / Early-onset sepsis in very low birth weight neonates:a report from the National Institute of Child Health and Human Development Neonatal Research Network / J Pediatrics 129:72~80
Stoll BJ / 2002 / Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants / N Engl J Med 347:240~247
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