Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

변윤형; 최정은; 박정영; 송정현; 여경준; 공은정; 강수환; 이수정

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자료유형: 학술저널

저자정보: 변윤형 최정은 박정영 송정현 여경준 공은정 강수환 이수정

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제17권 제3호

발행연도: 2017.1

수록면: 122 - 130 (9page)

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Purpose: Ultrasonography and computed tomography of the neck are commonly used for preoperative evaluation of neck lymph node (LN) status in papillary thyroid carcinoma (PTC). This study evaluated the accuracy of preoperative positron emission tomography/magnetic resonance (PET/MR) imaging of cervical LN status in PTC. Methods: A retrospective chart review of 285 patients who received PET/MR and underwent open thyroidectomy due to primary PTC between August 2012 and October 2013 was performed. Visual 18F-fluorodeoxyglucose uptake and preoperative morphologic abnormalities of nodal shape, cortical thickness, and the fatty hilum of neck nodes were analyzed using PET/MR imaging. Results: Total thyroidectomy and lobectomy were conducted in 78.2% (223/285) and 21.8% (62/285) of cases, respectively. The status of central neck LN were evaluated in all patients during surgery and additional evaluation of lateral neck LN were conducted in 11.9% (34/285) of patients through selective sampling or modified radical neck dissection. In total, 36.1% (103/285) of patients had pathologic neck LN metastasis (LNM). PET/MR imaging showed an accuracy of 68.8%, sensitivity of 32.7%, and specificity of 88.6% for the detection of central neck LNM; moreover, an accuracy of 95.1%, sensitivity 68.4%, and specificity of 97.0% for lateral neck LNM. PET/MR imaging showed higher accuracy for detecting neck LNM in the 164 patients who did not have suspected clinical thyroiditis than others. Conclusion: PET/MR has a high specificity for detecting central LNM, especially for patients diagnosed with PTC without pathologic thyroiditis.

#Lymphatic metastasis #Thyroid neoplasms #Positron-emission tomography

참고문헌 (21)

참고문헌 신청

Antoch G / 2009 / Combined PET/MRI: a new dimension in whole-body oncology imaging? / Eur J Nucl Med Mol Imaging 36 (Suppl 1) : S113 ~ S120

Binse I / 2016 / Imaging with (124)I in differentiated thyroid carcinoma: is PET/MRI superior to PET/CT? / Eur J Nucl Med Mol Imaging 43 : 1011 ~ 1017

Choi JS / 2009 / Preoperative staging of papillary thyroid carcinoma: comparison of ultrasound imaging and CT / AJR Am J Roentgenol 193 : 871 ~ 878

Dercle L / 2016 / Evaluation of (124)I PET/CT and (124)I PET/MRI in the management of patients with differentiated thyroid cancer / Eur J Nucl Med Mol Imaging 43 : 1006 ~ 10

Dietlein M / 1997 / Fluorine-18 fluorodeoxyglucose positron emission tomography and iodine-131 whole-body scintigraphy in the follow-up of differentiated thyroid cancer / Eu

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