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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Despite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with sarcopenia has been demonstrated in the general population. We investigated the association of heavy metals, including lead, mercury and cadmium, with sarcopenia in the Korean population.
Methods: Participants included 344 males and 360 females older than 65 years based on data from the fourth and fifth Korea National Health and Nutritional Examination Surveys. Measurements of blood lead, mercury and cadmium levels were performed. To evaluate the cumulative effect of the three heavy metals, subjects were categorized into quartiles. Sarcopenia was defined according to the criteria for the Asia Working Group for Sarcopenia (AWGS) (SMI<5.4 kg/m2 in females and <7.0 kg/m2 in males). Results: Of 704 elderly persons (344 in males and 360 in females), prevalences of sarcopenia were 26.7% (92/344) in male and 7.5% (27/360) in female. Mean serum levels of lead in sarcopenia group were significantly higher than non-sarcopenia males (P=0.03). After adjustment for confounding factors, odds ratio for sarcopenia were increased with concentration category of lead (P=0.005 and P<0.001), mercury (P=0.001 and P<0.001) and cadmium (P=0.010 and P<0.001) in males and females, respectively. Conclusions: This study demonstrates that high levels of blood lead, mercury and cadmium increase the prevalence of sarcopenia in both genders of elderly populations.
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참고문헌 (36)
참고문헌 신청
Henson MC / 2004 / Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction / Exp Biol Med 229:383~392
Kumar A / 2009 / Lead loadings in household dust in Delhi, India / Indoor Air 19:414~420
Rosin A / 2009 / The long-term consequences of exposure to lead / Isr Med Assoc J 11:689~694
Mercier M / 1990 / International approach of the assessment of chemical risks / J Hyg Epidemiol Microbiol Immunol 34:1~7
Nogawa K / 1993 / Biological monitoring of cadmium exposure in itai-itai disease epidemiology / Int Arch Occup Environ Health 65:S43~S46
Kumar A / 2009 / Lead loadings in household dust in Delhi, India / Indoor Air 19:414~420
Rosin A / 2009 / The long-term consequences of exposure to lead / Isr Med Assoc J 11:689~694
Mercier M / 1990 / International approach of the assessment of chemical risks / J Hyg Epidemiol Microbiol Immunol 34:1~7
Nogawa K / 1993 / Biological monitoring of cadmium exposure in itai-itai disease epidemiology / Int Arch Occup Environ Health 65:S43~S46
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