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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: The use of osteoanabolic agents to facilitate fracture healing has been of heightened interest to the field of orthopaedic trauma. This study aimed to evaluate the evidence of teriparatide for fracture healing and functional recovery in osteoporotic patients.
Methods: We performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Library using terms including “Fracture” [tiab] AND “Teriparatide [tiab] OR “PTH” [tiab]. Results: This systematic review included 6 randomized clinical trials, 4 well-controlled retrospective studies, and 1 retrospective post hoc subgroup analysis.
Fracture location was 2 in pelvis, 3 in proximal femur, 1 in distal femur, 1 in shoulder, 2 in wrist and 2 in spine. The use of teriparatide yielded positive effects on radiographic bone healing in 6 studies, but was not associated with better radiographic outcome in 3. In terms of functional recovery, teriparatide injection was related with decrease in pain or shorter time to mobilization in 6 studies, but not related with pain numerical scale and mobility in 3. Conclusions: Our findings suggest that teriparatide provide selective advantages to fracture healing or functional recovery in the management of osteoporotic fractures. A better understanding of the role of teriparatide on osteoporotic fractures requires greater evidences from large volume prospective trials.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Binder EF / 2004 / Effects of extended outpatient rehabilitation after hip fracture: a randomized controlled trial / JAMA 292 : 837 ~ 846
Chiang CY / 2013 / Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy / Bone 52 : 360 ~ 365
Kaufman JM / 2005 / Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy / Osteoporos Int 1
Kawaguchi H / 2010 / A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial / J Bone Miner Re
Komrakova M / 2010 / Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats / Bone 47
Chiang CY / 2013 / Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy / Bone 52 : 360 ~ 365
Kaufman JM / 2005 / Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy / Osteoporos Int 1
Kawaguchi H / 2010 / A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial / J Bone Miner Re
Komrakova M / 2010 / Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats / Bone 47
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Effects of Teriparatide on Treatment Outcomes in Osteoporotic Hip and Pelvic Bone Fractures: Meta-analysis and Systematic Review of Randomized Controlled Trials
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Non-operative Treatment of Osteoporotic Thoracolumbar Extension-distraction Fracture Using Teriparatide in Elderly Female Patient with Severe Osteoporosis under Inoperable Condition: A Case Report
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Reply on “teriparatide treatment for postmenopausal women with sacral insufficiency fracture”
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요추 후외방 유합술 또는 후방 추체간 유합술을 시행한 골다공증 여성 환자에서 Teriparatide의 효과
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More than 6 Months of Teriparatide Treatment Was More Effective for Bone Union than Shorter Treatment Following Lumbar Posterolateral Fusion Surgery
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Safety and efficacy in actual clinical practice of once-weekly subcutaneous teriparatide for osteoporosis patients with a high fracture risk
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Effect of Teriparatide on Healing of Atypical Femoral Fractures: A Systemic Review
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Utility of radius bone densitometry for the treatment of osteoporosis with once-weekly teriparatide therapy
Osteoporosis and Sarcopenia
2018 .01
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Teriparatide therapy without surgical treatment for medication-related osteonecrosis of the jaw: a report of two cases
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